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    Rerg RAS-like, estrogen-regulated, growth-inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 232441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rergprovided by MGI
    Official Full Name
    RAS-like, estrogen-regulated, growth-inhibitorprovided by MGI
    Primary source
    MGI:MGI:2665139
    See related
    Ensembl:ENSMUSG00000030222 AllianceGenome:MGI:2665139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in negative regulation of cell growth; negative regulation of cell population proliferation; and response to hormone. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in bladder; gonad; limb; and sensory organ. Orthologous to human RERG (RAS like estrogen regulated growth inhibitor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 26.0), bladder adult (RPKM 12.7) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rerg in Genome Data Viewer
    Location:
    6 G1; 6 66.73 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (137031822..137147494, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (137054825..137170496, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9680 Neighboring gene STARR-positive B cell enhancer mm9_chr6:136929021-136929322 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene predicted gene, 30055 Neighboring gene STARR-seq mESC enhancer starr_17616 Neighboring gene STARR-seq mESC enhancer starr_17617 Neighboring gene predicted gene, 52923 Neighboring gene predicted gene, 38914 Neighboring gene STARR-positive B cell enhancer mm9_chr6:137140638-137140939 Neighboring gene STARR-seq mESC enhancer starr_17624 Neighboring gene protein tyrosine phosphatase receptor type O Neighboring gene predicted gene, 52924 Neighboring gene STARR-seq mESC enhancer starr_17627 Neighboring gene epidermal growth factor receptor pathway substrate 8 Neighboring gene STARR-seq mESC enhancer starr_17628

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Region-specific gene expression profiling of early mouse mandible uncovered SATB2 as a key molecule for teeth patterning. Nevoránková P, et al. Sci Rep, 2024 Aug 6. PMID 39107332, Free PMC Article
    2. Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Nef S, et al. Dev Biol, 2005 Nov 15. PMID 16214126
    3. The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution. Li H, et al. Development, 2019 Jun 17. PMID 31118233, Free PMC Article
    4. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Bouma GJ, et al. Biol Reprod, 2010 Feb. PMID 19864314, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related and estrogen-regulated growth inhibitor
    NP_001157684.1
    NP_001157686.1
    NP_871788.1
    XP_036021981.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164212.1 → NP_001157684.1  ras-related and estrogen-regulated growth inhibitor isoform a

      See identical proteins and their annotated locations for NP_001157684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 each encode isoform a.
      Source sequence(s)
      AC122303, AC144767, AK133734
      Consensus CDS
      CCDS20663.1
      UniProtKB/Swiss-Prot
      Q8R367
      Related
      ENSMUSP00000113105.2, ENSMUST00000117919.8
      Conserved Domains (1) summary
      cd04146
      Location:8 → 169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    2. NM_001164214.1 → NP_001157686.1  ras-related and estrogen-regulated growth inhibitor isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC122303, AC144767, AK133734
      Consensus CDS
      CCDS51942.1
      UniProtKB/TrEMBL
      E9PUF8
      Related
      ENSMUSP00000113702.2, ENSMUST00000119610.4
      Conserved Domains (1) summary
      cl21455
      Location:8 → 150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_181988.2 → NP_871788.1  ras-related and estrogen-regulated growth inhibitor isoform a

      See identical proteins and their annotated locations for NP_871788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 each encode isoform a.
      Source sequence(s)
      AC122303, AC144767, AK133734
      Consensus CDS
      CCDS20663.1
      UniProtKB/Swiss-Prot
      Q8R367
      Related
      ENSMUSP00000032347.5, ENSMUST00000032347.11
      Conserved Domains (1) summary
      cd04146
      Location:8 → 169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      137031822..137147494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166088.1 → XP_036021981.1  ras-related and estrogen-regulated growth inhibitor isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:1 → 114
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R367.1 GenPept UniProtKB/Swiss-Prot:Q8R367

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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