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    Ttc29 tetratricopeptide repeat domain 29 [ Mus musculus (house mouse) ]

    Gene ID: 73301, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ttc29provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 29provided by MGI
    Primary source
    MGI:MGI:1920551
    See related
    Ensembl:ENSMUSG00000037101 AllianceGenome:MGI:1920551
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700031F13Rik
    Summary
    Involved in cilium movement. Located in sperm flagellum. Is expressed in 4th ventricle lateral recess and lateral ventricle choroid plexus. Human ortholog(s) of this gene implicated in spermatogenic failure 42. Orthologous to human TTC29 (tetratricopeptide repeat domain 29). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 31.7) See more
    Orthologs
    human all
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    Genomic context

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    See Ttc29 in Genome Data Viewer
    Location:
    8 C1; 8 36.86 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (78939911..79120955)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (78213282..78394326)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21968 Neighboring gene STARR-seq mESC enhancer starr_21971 Neighboring gene predicted gene 6360 Neighboring gene STARR-seq mESC enhancer starr_21973 Neighboring gene STARR-seq mESC enhancer starr_21976 Neighboring gene predicted gene 45574 Neighboring gene predicted gene, 39202 Neighboring gene STARR-seq mESC enhancer starr_21980 Neighboring gene STARR-seq mESC enhancer starr_21981 Neighboring gene STARR-seq mESC enhancer starr_21983 Neighboring gene STARR-seq mESC enhancer starr_21984 Neighboring gene POU domain, class 4, transcription factor 2 Neighboring gene predicted gene 2225

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice. Liu C, et al. Am J Hum Genet, 2019 Dec 5. PMID 31735294, Free PMC Article
    2. Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility. Lorès P, et al. Am J Hum Genet, 2019 Dec 5. PMID 31735292, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 29
    Names
    TPR repeat protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183096.3 → NP_898919.3  tetratricopeptide repeat protein 29

      See identical proteins and their annotated locations for NP_898919.3

      Status: VALIDATED

      Source sequence(s)
      AC117544, AC133181, AC140845
      Consensus CDS
      CCDS22428.1
      UniProtKB/Swiss-Prot
      Q80VM3, Q8CF30
      UniProtKB/TrEMBL
      E9QLU4
      Related
      ENSMUSP00000041919.9, ENSMUST00000049395.15
      Conserved Domains (2) summary
      TIGR02917
      Location:245 → 380
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:275 → 308
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      78939911..79120955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248517.3 → XP_011246819.1  tetratricopeptide repeat protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011246819.1

      UniProtKB/Swiss-Prot
      Q80VM3, Q8CF30
      UniProtKB/TrEMBL
      E9QLU4
      Conserved Domains (2) summary
      TIGR02917
      Location:245 → 380
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:275 → 308
      TPR; TPR repeat [structural motif]

    2. XM_011248518.3 → XP_011246820.1  tetratricopeptide repeat protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011246820.1

      UniProtKB/Swiss-Prot
      Q80VM3, Q8CF30
      UniProtKB/TrEMBL
      E9QLU4
      Conserved Domains (2) summary
      TIGR02917
      Location:245 → 380
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:275 → 308
      TPR; TPR repeat [structural motif]

    3. XM_011248516.3 → XP_011246818.1  tetratricopeptide repeat protein 29 isoform X1

      See identical proteins and their annotated locations for XP_011246818.1

      UniProtKB/Swiss-Prot
      Q80VM3, Q8CF30
      UniProtKB/TrEMBL
      E9QLU4
      Conserved Domains (2) summary
      TIGR02917
      Location:245 → 380
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:275 → 308
      TPR; TPR repeat [structural motif]

    4. XM_006531400.2 → XP_006531463.1  tetratricopeptide repeat protein 29 isoform X1

      See identical proteins and their annotated locations for XP_006531463.1

      UniProtKB/Swiss-Prot
      Q80VM3, Q8CF30
      UniProtKB/TrEMBL
      E9QLU4
      Related
      ENSMUSP00000105528.3, ENSMUST00000109902.4
      Conserved Domains (2) summary
      TIGR02917
      Location:245 → 380
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:275 → 308
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VM3.1 GenPept UniProtKB/Swiss-Prot:Q80VM3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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