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    Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 [ Mus musculus (house mouse) ]

    Gene ID: 13089, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp2b13provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily b, polypeptide 13provided by MGI
    Primary source
    MGI:MGI:88599
    See related
    Ensembl:ENSMUSG00000040583 AllianceGenome:MGI:88599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable heme binding activity and monooxygenase activity. Predicted to be involved in several processes, including epoxygenase P450 pathway; steroid metabolic process; and xenobiotic catabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver adult (RPKM 50.7) See more
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    Genomic context

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    See Cyp2b13 in Genome Data Viewer
    Location:
    7 A3; 7 14.11 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25760813..25795622)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26061388..26096197)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 27, pseudogene Neighboring gene predicted gene, 51474 Neighboring gene ring finger protein 170, pseudogene Neighboring gene protein LTV1 homolog Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 26, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a cDNA clone for mouse phenobarbital-inducible cytochrome P-450b. Stupans I, et al. DNA, 1984. PMID 6547088
    2. Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution. Lakso M, et al. Eur J Biochem, 1991 Jan 30. PMID 1997326
    3. Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function. Damiri B, et al. Toxicol Sci, 2012 Feb. PMID 22083726, Free PMC Article
    4. Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Lundgren M, et al. Toxicology, 2007 Dec 5. PMID 17964055
    5. Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster. Wang H, et al. Environ Health Perspect, 2003 Nov. PMID 14630516, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report lentiviral-mediated RNAi knockdown of multiple mouse Cyp2b enzymes.
      Title: Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anandamide 11,12 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 14,15 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anandamide 8,9 epoxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estrogen 2-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 16-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily b, polypeptide 13
    Names
    cytochrome P450, 2b13, phenobarbitol inducible, type c
    phenobarbital inducible, type c

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007813.2 → NP_031839.2  cytochrome P450, family 2, subfamily b, polypeptide 13 precursor

      See identical proteins and their annotated locations for NP_031839.2

      Status: VALIDATED

      Source sequence(s)
      AC167357, AC171401, BC145895
      Consensus CDS
      CCDS21000.2
      UniProtKB/TrEMBL
      A6H6J2, E9Q713, Q64460
      Related
      ENSMUSP00000005669.8, ENSMUST00000005669.9
      Conserved Domains (1) summary
      pfam00067
      Location:42 → 488
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25760813..25795622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539508.4 → XP_006539571.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X1

      See identical proteins and their annotated locations for XP_006539571.1

      UniProtKB/TrEMBL
      Q64460
      Conserved Domains (1) summary
      pfam00067
      Location:82 → 514
      p450; Cytochrome P450

    2. XM_006539509.4 → XP_006539572.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X1

      See identical proteins and their annotated locations for XP_006539572.1

      UniProtKB/TrEMBL
      Q64460
      Conserved Domains (1) summary
      pfam00067
      Location:82 → 514
      p450; Cytochrome P450

    3. XM_006539510.4 → XP_006539573.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X2

      Conserved Domains (1) summary
      pfam00067
      Location:82 → 455
      p450; Cytochrome P450

    4. XM_006539511.2 → XP_006539574.1  cytochrome P450, family 2, subfamily b, polypeptide 13 isoform X3

      Conserved Domains (1) summary
      pfam00067
      Location:2 → 381
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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