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    Dbx2 developing brain homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 223843, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dbx2provided by MGI
    Official Full Name
    developing brain homeobox 2provided by MGI
    Primary source
    MGI:MGI:107445
    See related
    Ensembl:ENSMUSG00000045608 AllianceGenome:MGI:107445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1229; 9630005K15; 9430056A22Rik
    Summary
    Acts upstream of or within several processes, including G2/M transition of mitotic cell cycle; epidermal growth factor receptor signaling pathway; and neural precursor cell proliferation. Is expressed in several structures, including central nervous system; limb; limb bud; sensory organ; and tooth mesenchyme. Orthologous to human DBX2 (developing brain homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 5.6), frontal lobe adult (RPKM 5.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dbx2 in Genome Data Viewer
    Location:
    15 E3; 15 50.47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (95521444..95552838, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (95623563..95654771, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31551 Neighboring gene predicted gene, 24668 Neighboring gene VISTA enhancer mm1571 Neighboring gene predicted gene, 31690 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:95556425-95556608 Neighboring gene actin related protein 2/3 complex, subunit 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_39569 Neighboring gene predicted gene 6961

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors. Giuliani A, et al. Stem Cell Rev Rep, 2023 Nov. PMID 37605090, Free PMC Article
    2. Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline. Lupo G, et al. Aging Cell, 2018 Jun. PMID 29504228, Free PMC Article
    3. Regionalized expression of the Dbx family homeobox genes in the embryonic CNS of the mouse. Shoji H, et al. Mech Dev, 1996 May. PMID 8798145
    4. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord. Pierani A, et al. Cell, 1999 Jun 25. PMID 10399918
    5. A role for HOX13 proteins in the regulatory switch between TADs at the HoxD locus. Beccari L, et al. Genes Dev, 2016 May 15. PMID 27198226, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors.
      Title: Dbx2, an Aging-Related Homeobox Gene, Inhibits the Proliferation of Adult Neural Progenitors.
    2. Results provide new insights into the molecular programmes that are affected during mouse NSPC aging, and uncover a new functional role for Dbx2 in promoting age-related neurogenic decline.
      Title: Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neural precursor cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein DBX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207533.2 → NP_997416.2  homeobox protein DBX2

      See identical proteins and their annotated locations for NP_997416.2

      Status: VALIDATED

      Source sequence(s)
      AK035803, CX214447, CX214957
      Consensus CDS
      CCDS37183.1
      UniProtKB/TrEMBL
      F8VQH7
      Related
      ENSMUSP00000060424.7, ENSMUST00000054244.7
      Conserved Domains (2) summary
      COG5576
      Location:217 → 334
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:229 → 282
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      95521444..95552838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159373.1 → XP_036015266.1  homeobox protein DBX2 isoform X1

      Conserved Domains (2) summary
      COG5576
      Location:185 → 302
      COG5576; Homeodomain-containing transcription factor [Transcription]
      pfam00046
      Location:197 → 251
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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