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    FCGBP Fc gamma binding protein [ Homo sapiens (human) ]

    Gene ID: 8857, updated on 5-Jan-2025

    Summary

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    Official Symbol
    FCGBPprovided by HGNC
    Official Full Name
    Fc gamma binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13572
    See related
    Ensembl:ENSG00000275395 MIM:617553; AllianceGenome:HGNC:13572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FC(GAMMA)BP
    Summary
    Located in extracellular exosome. [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Expression
    Biased expression in colon (RPKM 352.9), thyroid (RPKM 129.4) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCGBP in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39863323..39934634, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42668261..42770240, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40353963..40440541, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10614 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1B Neighboring gene microRNA 6719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40335824-40336564 Neighboring gene fibrillarin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40357069-40358268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40376357-40376858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40433231-40433732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40449389-40449889 Neighboring gene Sharpr-MPRA regulatory region 5808 Neighboring gene proline rich 13 pseudogene 5 Neighboring gene uncharacterized LOC124904722 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:40465439-40466248

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stamp LA, et al. Stem Cells, 2012 Sep. PMID 22761039, Free PMC Article
    2. The molecular configuration and ultrastructural locations of an IgG Fc binding site in human colonic epithelium. Kobayashi K, et al. J Immunol, 1991 Jan 1. PMID 1984453
    3. Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure. Harada N, et al. J Biol Chem, 1997 Jun 13. PMID 9182547
    4. Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases. Kobayashi K, et al. Immunol Lett, 2001 Dec 3. PMID 11600203
    5. Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas. O'Donovan N, et al. J Endocrinol, 2002 Sep. PMID 12208673

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment.
      Title: Non-coding RNA-related FCGBP downregulation in head and neck squamous cell carcinoma: a novel biomarker for predicting paclitaxel resistance and immunosuppressive microenvironment.
    2. Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA.
      Title: Revealing the role of necroptosis microenvironment: FCGBP + tumor-associated macrophages drive primary liver cancer differentiation towards cHCC-CCA or iCCA.
    3. [IgG Fc binding protein (FCGBP) as a prognostic marker of low-grade glioma and its correlation analysis with immune infiltration].
      Title: [IgG Fc binding protein (FCGBP) as a prognostic marker of low-grade glioma and its correlation analysis with immune infiltration].
    4. Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma.
      Title: Fc fragment of IgG binding protein is correlated with immune infiltration levels in hepatocellular carcinoma.
    5. Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer.
      Title: Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer.
    6. FCGBP Is a Promising Prognostic Biomarker and Correlates with Immunotherapy Efficacy in Oral Squamous Cell Carcinoma.
      Title: FCGBP Is a Promising Prognostic Biomarker and Correlates with Immunotherapy Efficacy in Oral Squamous Cell Carcinoma.
    7. FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis.
      Title: FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis.
    8. IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study.
      Title: IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study.
    9. The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.
      Title: The IgGFc-binding protein FCGBP is secreted with all GDPH sequences cleaved but maintained by interfragment disulfide bonds.
    10. A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer.
      Title: A bioinformatic analysis: the overexpression and clinical significance of FCGBP in ovarian cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    IgGFc-binding protein
    Names
    Fc fragment of IgG binding protein
    Human Fc gamma BP
    IgG Fc binding protein
    fcgamma-binding protein antigen
    fcgammaBP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003890.3 → NP_003881.2  IgGFc-binding protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC006950, AC007842, AC011536
      UniProtKB/Swiss-Prot
      O95784, Q9Y6R7
      Related
      ENSP00000481056.3, ENST00000616721.6
      Conserved Domains (5) summary
      smart00832
      Location:667 → 742
      C8; This domain contains 8 conserved cysteine residues
      pfam00094
      Location:472 → 627
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:2337 → 2390
      TIL; Trypsin Inhibitor like cysteine rich domain
      cl02516
      Location:5235 → 5382
      VWD; von Willebrand factor type D domain
      cl17735
      Location:1194 → 1245
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39863323..39934634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p14 PATCHES

      Range
      123199..225173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331644.1 → XP_054187619.1  IgGFc-binding protein isoform X1

      UniProtKB/Swiss-Prot
      O95784, Q9Y6R7

    2. XM_054331643.1 → XP_054187618.1  IgGFc-binding protein isoform X1

      UniProtKB/Swiss-Prot
      O95784, Q9Y6R7

    3. XM_054331645.1 → XP_054187620.1  IgGFc-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A087WXI2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42668261..42770240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322489.1 → XP_054178464.1  IgGFc-binding protein isoform X1

    2. XM_054322488.1 → XP_054178463.1  IgGFc-binding protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6R7.3 GenPept UniProtKB/Swiss-Prot:Q9Y6R7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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