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    Hepacam2 HEPACAM family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 101202, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Hepacam2provided by MGI
    Official Full Name
    HEPACAM family member 2provided by MGI
    Primary source
    MGI:MGI:2141520
    See related
    Ensembl:ENSMUSG00000044156 AllianceGenome:MGI:2141520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in centrosome cycle. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be active in Golgi apparatus; microtubule cytoskeleton; and midbody. Is expressed in brain and foregut-midgut junction. Orthologous to human HEPACAM2 (HEPACAM family member 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in colon adult (RPKM 18.5), large intestine adult (RPKM 13.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hepacam2 in Genome Data Viewer
    Location:
    6 A1; 6 1.8 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (3457202..3498319, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (3457089..3498322, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14986 Neighboring gene STARR-positive B cell enhancer ABC_E9269 Neighboring gene predicted gene, 20559 Neighboring gene STARR-seq mESC enhancer starr_14987 Neighboring gene STARR-seq mESC enhancer starr_14988 Neighboring gene STARR-seq mESC enhancer starr_14989 Neighboring gene STARR-positive B cell enhancer mm9_chr6:3349393-3349694 Neighboring gene sterile alpha motif domain containing 9-like Neighboring gene STARR-seq mESC enhancer starr_14990 Neighboring gene STARR-seq mESC enhancer starr_14991 Neighboring gene STARR-positive B cell enhancer ABC_E6412 Neighboring gene STARR-positive B cell enhancer ABC_E9270 Neighboring gene VPS50 EARP/GARPII complex subunit Neighboring gene STARR-seq mESC enhancer starr_14997 Neighboring gene predicted gene, 52885 Neighboring gene STARR-seq mESC enhancer starr_14998 Neighboring gene STARR-seq mESC enhancer starr_14999 Neighboring gene STARR-seq mESC enhancer starr_15001 Neighboring gene STARR-seq mESC enhancer starr_15002 Neighboring gene predicted gene, 53306

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
    2. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    3. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    HEPACAM family member 2
    Names
    mitotic kinetics regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411485.1 → NP_001398414.1  HEPACAM family member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC022453, AC027655

    2. NM_178899.6 → NP_849230.1  HEPACAM family member 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC022453
      Consensus CDS
      CCDS39414.1
      UniProtKB/Swiss-Prot
      Q4VAH7
      Related
      ENSMUSP00000058882.8, ENSMUST00000049985.15
      Conserved Domains (3) summary
      PHA02826
      Location:184 → 322
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00096
      Location:167 → 233
      Ig; Immunoglobulin domain
      cl11960
      Location:36 → 143
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      3457202..3498319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504960.3 → XP_006505023.1  HEPACAM family member 2 isoform X6

      Conserved Domains (3) summary
      PHA02826
      Location:108 → 246
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00096
      Location:91 → 157
      Ig; Immunoglobulin domain
      cl11960
      Location:30 → 99
      Ig; Immunoglobulin domain

    2. XM_030255044.2 → XP_030110904.1  HEPACAM family member 2 isoform X6

      Conserved Domains (3) summary
      PHA02826
      Location:108 → 246
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00096
      Location:91 → 157
      Ig; Immunoglobulin domain
      cl11960
      Location:30 → 99
      Ig; Immunoglobulin domain

    3. XM_006504958.3 → XP_006505021.1  HEPACAM family member 2 isoform X4

      Conserved Domains (3) summary
      PHA02826
      Location:183 → 321
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00096
      Location:166 → 232
      Ig; Immunoglobulin domain
      cl11960
      Location:35 → 142
      Ig; Immunoglobulin domain

    4. XM_006504957.3 → XP_006505020.1  HEPACAM family member 2 isoform X1

      Related
      ENSMUST00000201276.2
      Conserved Domains (2) summary
      cd00096
      Location:168 → 234
      Ig; Immunoglobulin domain
      cl11960
      Location:37 → 144
      Ig; Immunoglobulin domain

    5. XM_030255043.1 → XP_030110903.1  HEPACAM family member 2 isoform X5

      Conserved Domains (3) summary
      PHA02826
      Location:183 → 321
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00096
      Location:166 → 232
      Ig; Immunoglobulin domain
      cl11960
      Location:35 → 142
      Ig; Immunoglobulin domain

    6. XM_030255042.1 → XP_030110902.1  HEPACAM family member 2 isoform X3

      UniProtKB/Swiss-Prot
      Q4VAH7
      Conserved Domains (3) summary
      PHA02826
      Location:184 → 322
      PHA02826; IL-1 receptor-like protein; Provisional
      cd00096
      Location:167 → 233
      Ig; Immunoglobulin domain
      cl11960
      Location:36 → 143
      Ig; Immunoglobulin domain

    7. XM_030255041.1 → XP_030110901.1  HEPACAM family member 2 isoform X2

      Conserved Domains (2) summary
      cd00096
      Location:168 → 234
      Ig; Immunoglobulin domain
      cl11960
      Location:37 → 144
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VAH7.1 GenPept UniProtKB/Swiss-Prot:Q4VAH7

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