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    Tmem182 transmembrane protein 182 [ Mus musculus (house mouse) ]

    Gene ID: 381339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem182provided by MGI
    Official Full Name
    transmembrane protein 182provided by MGI
    Primary source
    MGI:MGI:1923725
    See related
    Ensembl:ENSMUSG00000079588 AllianceGenome:MGI:1923725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310079P10Rik
    Summary
    Involved in myotube cell development involved in skeletal muscle regeneration; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Predicted to be located in plasma membrane. Orthologous to human TMEM182 (transmembrane protein 182). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 42.4), subcutaneous fat pad adult (RPKM 17.7) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem182 in Genome Data Viewer
    Location:
    1 B; 1 20.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40844738..40896047)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40805573..40856887)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 2 Neighboring gene predicted gene, 37915 Neighboring gene major facilitator superfamily domain containing 9 Neighboring gene STARR-seq mESC enhancer starr_00745 Neighboring gene peptidyl-prolyl cis-trans isomerase A pseudogene 1_352.1 Neighboring gene STARR-seq mESC enhancer starr_00746 Neighboring gene STARR-seq mESC enhancer starr_00748 Neighboring gene STARR-seq mESC enhancer starr_00749 Neighboring gene STARR-seq mESC enhancer starr_00750 Neighboring gene STARR-seq mESC enhancer starr_00751 Neighboring gene STARR-seq mESC enhancer starr_00752 Neighboring gene STARR-seq mESC enhancer starr_00754 Neighboring gene RIKEN cDNA 4930448I06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics. Chen G, et al. Int J Biol Macromol, 2024 Feb. PMID 38181918
    2. TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration. Luo W, et al. J Cachexia Sarcopenia Muscle, 2021 Dec. PMID 34427057, Free PMC Article
    3. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics.
      Title: The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics.
    2. TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration.
      Title: TMEM182 interacts with integrin beta 1 and regulates myoblast differentiation and muscle regeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myotube cell development involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myotube differentiation involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 182

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081198.1 → NP_001074667.1  transmembrane protein 182 precursor

      See identical proteins and their annotated locations for NP_001074667.1

      Status: PROVISIONAL

      Source sequence(s)
      AC154392
      Consensus CDS
      CCDS35550.1
      UniProtKB/Swiss-Prot
      B2RVY9
      Related
      ENSMUSP00000110413.3, ENSMUST00000114765.4
      Conserved Domains (1) summary
      pfam13903
      Location:15 → 220
      Claudin_2; PMP-22/EMP/MP20/Claudin tight junction

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40844738..40896047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321461.2 → XP_017176950.1  transmembrane protein 182 isoform X1

      Conserved Domains (1) summary
      cl21598
      Location:13 → 167
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. XM_036166211.1 → XP_036022104.1  transmembrane protein 182 isoform X2

      Conserved Domains (1) summary
      cl21598
      Location:9 → 118
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RVY9.1 GenPept UniProtKB/Swiss-Prot:B2RVY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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