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    CG31115 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318597, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31115provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051115
    Locus tag
    Dmel_CG31115
    See related
    AllianceGenome:FB:FBgn0051115
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG31115
    Summary
    Predicted to enable S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to be active in cytosol. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31115 in Genome Data Viewer
    Location:
    96B17-96B17; 3-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25036944..25037982)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20862666..20863704)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Hormone receptor-like in 96 Neighboring gene Smg6 Neighboring gene YTH N6-methyladenosine RNA binding protein Neighboring gene Inositol polyphosphate-5-phosphatase type I Neighboring gene baiser Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article
    2. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
    3. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables S-methyl-5-thioadenosine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-methyl-5-thioadenosine phosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31115-PB
    NP_733068.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25036944..25037982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170189.3 → NP_733068.2  uncharacterized protein Dmel_CG31115 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733068.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IMU4
      UniProtKB/TrEMBL
      C7LA98
      Conserved Domains (2) summary
      COG0005
      Location:12 → 266
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      cl00303
      Location:19 → 264
      PNP_UDP_1; Phosphorylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMU4.2 Q8IMU4

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