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    Acbp1 Acyl-CoA binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34111, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Acbp1provided by FlyBase
    Official Full Name
    Acyl-CoA binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031992
    Locus tag
    Dmel_CG8498
    See related
    AllianceGenome:FB:FBgn0031992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACBP; CG8498; DmCG8498; Dmel\CG8498
    Summary
    Predicted to enable fatty-acyl-CoA binding activity. Predicted to be involved in fatty acid metabolic process. Is expressed in several structures, including embryonic Malpighian tubule; gut section; larval muscle system; and trunk mesoderm. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to several human genes including ACBD7 (acyl-CoA binding domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acbp1 in Genome Data Viewer
    Location:
    28E9-28E9; 2-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8161796..8162452, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8161796..8162452, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phosphatidic Acid Phospholipase A1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rabenosyn-5 Neighboring gene piezo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ACBP gene family in Rhodnius prolixus: Expression, characterization and function of RpACBP-1. Majerowicz D, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001070
    2. New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms. Kors S, et al. Biochim Biophys Acta Mol Cell Res, 2024 Dec. PMID 39271061
    3. The genetic relationships between ethanol preference, acute ethanol sensitivity, and ethanol tolerance in Drosophila melanogaster. Devineni AV, et al. Fly (Austin), 2011 Jul-Sep. PMID 21750412, Free PMC Article
    4. A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila. Li X, et al. Nat Commun, 2023 Nov 21. PMID 37989752, Free PMC Article
    5. A botanical containing freeze dried açai pulp promotes healthy aging and reduces oxidative damage in sod1 knockdown flies. Laslo M, et al. Age (Dordr), 2013 Aug. PMID 22639178, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA binding protein 1
    Names
    Acbp1-PA
    Acbp1-PB
    CG8498-PA
    CG8498-PB
    acyl-CoA-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8161796..8162452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298815.1 → NP_001285744.1  Acyl-CoA binding protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLS4
      Conserved Domains (1) summary
      cd00435
      Location:5 → 87
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

    2. NM_135343.4 → NP_609187.1  Acyl-CoA binding protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLS4
      Related
      FBpp0079256
      Conserved Domains (1) summary
      cd00435
      Location:5 → 87
      ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLS4 Q9VLS4

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