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    Adsl Adenylosuccinate lyase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adslprovided by FlyBase
    Official Full Name
    Adenylosuccinate lyaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038467
    Locus tag
    Dmel_CG3590
    See related
    AllianceGenome:FB:FBgn0038467
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AdSL; CG3590; Dmel\CG3590
    Summary
    Predicted to enable (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity and N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity. Predicted to be involved in 'de novo' AMP biosynthetic process. Predicted to be active in cytosol. Is expressed in adult head. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adsl in Genome Data Viewer
    Location:
    89E8-89E8; 3-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17018780..17021120, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12844502..12846842, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Immune-regulated catalase Neighboring gene uncharacterized protein Neighboring gene Peroxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
    2. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Stenesen D, et al. Cell Metab, 2013 Jan 8. PMID 23312286, Free PMC Article
    3. Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila. Wang R, et al. Nat Commun, 2022 Jun 20. PMID 35725845, Free PMC Article
    4. Habituation Learning Is a Widely Affected Mechanism in Drosophila Models of Intellectual Disability and Autism Spectrum Disorders. Fenckova M, et al. Biol Psychiatry, 2019 Aug 15. PMID 31272685, Free PMC Article
    5. Time-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models. Livelo C, et al. Nat Commun, 2023 Feb 21. PMID 36810287, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' AMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in purine ribonucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adenylosuccinate lyase
    Names
    Adsl-PA
    CG3590-PA
    NP_650586.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17018780..17021120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142329.4 → NP_650586.2  adenylosuccinate lyase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650586.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SP9, Q9VEP6
      Related
      FBpp0082816
      Conserved Domains (2) summary
      cd03302
      Location:12 → 447
      Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2
      COG0015
      Location:12 → 458
      PurB; Adenylosuccinate lyase [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SP9 Q95SP9
    Q9VEP6 Q9VEP6

    Gene LinkOut

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