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    PolZ1 DNA polymerase zeta subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolZ1provided by FlyBase
    Official Full Name
    DNA polymerase zeta subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0002891
    Locus tag
    Dmel_CG1925
    See related
    AllianceGenome:FB:FBgn0002891
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154926_at; AAF59191; CG1925; DhRev3; Dmel\CG1925; Dmpolzeta; DmREV3; DNApol-zeta; mus 205; mus(2)205; mus-205; mus205; Mus205; rev3; Rev3
    Summary
    Enables DNA-directed DNA polymerase activity. Involved in DNA synthesis involved in double-strand break repair via homologous recombination. Part of zeta DNA polymerase complex. Is expressed in spermatozoon and wing disc. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolZ1 in Genome Data Viewer
    Location:
    43E17-43E17; 2-57 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7793625..7801044)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3681130..3688549)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glyceraldehyde 3 phosphate dehydrogenase 1 Neighboring gene Nop17 like Neighboring gene saxophone Neighboring gene Tubulin tyrosine ligase-like 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila DNA polymerase zeta interacts with recombination repair protein 1, the Drosophila homologue of human abasic endonuclease 1. Takeuchi R, et al. J Biol Chem, 2006 Apr 28. PMID 16507570
    2. Isolation and characterization of a photorepair-deficient mutant in Drosophila melanogaster. Boyd JB, et al. Genetics, 1987 Jun. PMID 3111935, Free PMC Article
    3. Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila. Kane DP, et al. PLoS Genet, 2012. PMID 22532806, Free PMC Article
    4. A rapid somatic genotoxicity assay in Drosophila melanogaster using multiple mutant mutagen-sensitive (mus) strains. Henderson DS, et al. Mutagenesis, 1992 Nov. PMID 1474914
    5. Isolation and characterization of second chromosome mutagen-sensitive mutations in Drosophila melanogaster. Henderson DS, et al. Mutat Res, 1987 Mar. PMID 3102956

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables 3'-5' exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA synthesis involved in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA synthesis involved in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in error-prone translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translesion synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zeta DNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase zeta subunit 1
    Names
    CG1925-PA
    DNA polymerase zeta catalytic subunit
    PolZ1-PA
    mutagen-sensitive 205
    NP_524881.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7793625..7801044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080142.3 → NP_524881.2  DNA polymerase zeta subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524881.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TM2, Q9GSR1, Q9GSR2, Q9V319
      Related
      FBpp0087907
      Conserved Domains (4) summary
      cd05778
      Location:1297 → 1518
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:1550 → 2000
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      PTZ00166
      Location:20 → 196
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:2041 → 2107
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9GSR1.1 Q9GSR1

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