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    Usp2 Ubiquitin specific protease 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33132, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp2provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031187
    Locus tag
    Dmel_CG14619
    See related
    AllianceGenome:FB:FBgn0031187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14619; Dmel\CG14619; dUsp2; Q9VR54; USP2
    Summary
    Enables K48-linked deubiquitinase activity and proteasome binding activity. Involved in several processes, including negative regulation of defense response; positive regulation of eclosion; and positive regulation of proteasomal protein catabolic process. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human USP2 (ubiquitin specific peptidase 2) and USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp2 in Genome Data Viewer
    Location:
    20C1-20C1; 1-66 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (22455803..22470146)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21857639..21871982)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene touch insensitive larva B Neighboring gene wings apart Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Centriolar coiled coil protein 110kDa Neighboring gene lethal (1) G0196

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isoleucine 44 Hydrophobic Patch Controls Toxicity of Unanchored, Linear Ubiquitin Chains through NF-κB Signaling. Blount JR, et al. Cells, 2020 Jun 22. PMID 32580388, Free PMC Article
    2. USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level. Pouly D, et al. PLoS One, 2016. PMID 26756164, Free PMC Article
    3. The Drosophila wings apart gene anchors a novel, evolutionarily conserved pathway of neuromuscular development. Morriss GR, et al. Genetics, 2013 Nov. PMID 24026097, Free PMC Article
    4. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article
    5. Proapoptotic function of deubiquitinase DUSP31 in Drosophila. Sinenko SA. Oncotarget, 2017 Sep 19. PMID 29050293, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22458695-22460157 mobile_element_type = transposon:HB{}248

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables proteasome binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of eclosion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin specific protease 2
    Names
    CG14619-PA
    CG14619-PC
    CG14619-PD
    CG14619-PE
    CG14619-PF
    CG14619-PG
    CG14619-PH
    CG14619-PI
    CG14619-PK
    Usp2-PA
    Usp2-PC
    Usp2-PD
    Usp2-PE
    Usp2-PF
    Usp2-PG
    Usp2-PH
    Usp2-PI
    Usp2-PK
    NP_001245799.1
    NP_001245800.1
    NP_001285527.1
    NP_001285528.1
    NP_608462.1
    NP_728453.1
    NP_728454.1
    NP_728455.1
    NP_728456.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      22455803..22470146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298598.1 → NP_001285527.1  ubiquitin specific protease 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JLM6
      Conserved Domains (2) summary
      cd02674
      Location:241 → 563
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:239 → 562
      UCH; Ubiquitin carboxyl-terminal hydrolase

    2. NM_001258871.2 → NP_001245800.1  ubiquitin specific protease 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245800.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ27, Q8T9E4, Q9VR54
      Conserved Domains (1) summary
      pfam00443
      Location:613 → 935
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. NM_167776.3 → NP_728454.1  ubiquitin specific protease 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ27
      Related
      FBpp0077038
      Conserved Domains (2) summary
      cd02674
      Location:532 → 854
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:530 → 853
      UCH; Ubiquitin carboxyl-terminal hydrolase

    4. NM_167777.3 → NP_728455.1  ubiquitin specific protease 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728455.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ27, Q8T9E4, Q9VR54
      Related
      FBpp0077041
      Conserved Domains (1) summary
      pfam00443
      Location:613 → 935
      UCH; Ubiquitin carboxyl-terminal hydrolase

    5. NM_001298599.1 → NP_001285528.1  ubiquitin specific protease 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JG37
      Conserved Domains (2) summary
      cd02674
      Location:626 → 948
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:624 → 947
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. NM_001258870.2 → NP_001245799.1  ubiquitin specific protease 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245799.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ27, Q8T9E4, Q9VR54
      Conserved Domains (1) summary
      pfam00443
      Location:613 → 935
      UCH; Ubiquitin carboxyl-terminal hydrolase

    7. NM_167775.2 → NP_728453.1  ubiquitin specific protease 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ27
      Related
      FBpp0077039
      Conserved Domains (2) summary
      cd02674
      Location:532 → 854
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:530 → 853
      UCH; Ubiquitin carboxyl-terminal hydrolase

    8. NM_134618.3 → NP_608462.1  ubiquitin specific protease 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ27
      Related
      FBpp0077040
      Conserved Domains (2) summary
      cd02674
      Location:532 → 854
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:530 → 853
      UCH; Ubiquitin carboxyl-terminal hydrolase

    9. NM_167778.2 → NP_728456.2  ubiquitin specific protease 2, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ26
      Conserved Domains (2) summary
      cd02674
      Location:73 → 313
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1 → 312
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQ26 Q8IQ26
    Q8IQ27.1 Q8IQ27
    X2JG37 X2JG37
    X2JLM6 X2JLM6

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