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    Hspa1a heat shock protein 1A [ Mus musculus (house mouse) ]

    Gene ID: 193740, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hspa1aprovided by MGI
    Official Full Name
    heat shock protein 1Aprovided by MGI
    Primary source
    MGI:MGI:96244
    See related
    Ensembl:ENSMUSG00000091971 AllianceGenome:MGI:96244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsp72; hsp68; Hsp70-3; Hsp70.3; hsp70A1
    Summary
    Enables protein folding chaperone. Involved in lysosomal transport and protein folding. Acts upstream of or within DNA repair; response to heat; and telomere maintenance. Located in cytoplasm. Is expressed in several structures, including adrenal gland; crista ampullaris; early conceptus; genitourinary system; and vibrissa. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to human HSPA1A (heat shock protein family A (Hsp70) member 1A) and HSPA1B (heat shock protein family A (Hsp70) member 1B). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Hspa1a in Genome Data Viewer
    Location:
    17 B1; 17 18.51 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35188335..35191132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34969359..34972156, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene NHP2 non-histone chromosome protein 2-like 1 pseudogene Neighboring gene heat shock protein 1B Neighboring gene STARR-positive B cell enhancer ABC_E5598 Neighboring gene heat shock protein 1-like Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC189852

    Gene Ontology Provided by MGI

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent protein disaggregase activity  
    enables ATP-dependent protein folding chaperone  
    enables C3HC4-type RING finger domain binding  
    enables G protein-coupled receptor binding  
    enables NF-kappaB binding  
    enables death receptor agonist activity  
    enables denatured protein binding  
    enables disordered domain specific binding  
    enables double-stranded RNA binding PubMed 
    enables enzyme binding  
    enables heat shock protein binding  
    enables heat shock protein binding  
    enables histone deacetylase binding  
    enables misfolded protein binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein folding chaperone  
    enables protein folding chaperone PubMed 
    enables protein folding chaperone  
    enables receptor ligand activity  
    enables signaling receptor binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    enables ubiquitin protein ligase binding  
    enables unfolded protein binding  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair PubMed 
    involved_in chaperone cofactor-dependent protein refolding  
    involved_in lysosomal transport PubMed 
    involved_in mRNA catabolic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of microtubule nucleation  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in protein folding PubMed 
    involved_in protein refolding  
    involved_in protein refolding  
    involved_in regulation of mitotic spindle assembly  
    acts_upstream_of_or_within response to heat PubMed 
    acts_upstream_of_or_within response to heat PubMed 
    involved_in response to unfolded protein  
    acts_upstream_of_or_within telomere maintenance PubMed 
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    part_of COP9 signalosome  
    located_in aggresome  
    located_in apical plasma membrane  
    located_in basolateral plasma membrane  
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in inclusion body  
    located_in membrane raft  
    located_in mitochondrion PubMed 
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    part_of protein-containing complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    heat shock 70 kDa protein 1A
    Names
    68 kDa heat shock protein
    heat shock 70 kDa protein 3
    heat shock 70kDa protein 1A
    heat shock protein, 70 kDa 3
    inducible heat shock protein 70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010479.2NP_034609.2  heat shock 70 kDa protein 1A

      See identical proteins and their annotated locations for NP_034609.2

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS50080.1
      UniProtKB/Swiss-Prot
      Q61696, Q61697, Q7TQD8, Q9QWJ5
      UniProtKB/TrEMBL
      Q3TAI8, Q3TU85
      Related
      ENSMUSP00000084586.3, ENSMUST00000087328.4
      Conserved Domains (2) summary
      cd10233
      Location:6381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1641
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35188335..35191132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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