Tex15 testis expressed gene 15 meiosis and synapsis associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tex15provided by MGI
Official Full Name: testis expressed gene 15 meiosis and synapsis associatedprovided by MGI
Primary source: MGI:MGI:1934816
See related: Ensembl:ENSMUSG00000009628 AllianceGenome:MGI:1934816
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2210014E14Rik
Summary: Involved in retrotransposon silencing by piRNA-directed DNA methylation. Acts upstream of or within with a positive effect on DNA methylation-dependent heterochromatin formation. Acts upstream of or within several processes, including male genitalia development; meiotic nuclear division; and regulation of double-strand break repair via homologous recombination. Located in cytoplasm and nucleus. Is expressed in meninges; oocyte; sensory organ; and spinal cord mantle layer. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 4.1), testis adult (RPKM 3.8) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 20.59 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (34006712..34082531)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (33516689..33592503)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TEX15 associates with MILI and silences transposable elements in male germ cells.
Title: TEX15 associates with MILI and silences transposable elements in male germ cells.
TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
Title: TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.
Loss of TEX15 leads to DNA hypomethylation and de-silencing of transposable elements, at a level comparable to loss of MILI or DNMT3C but not MIWI2. TEX15 is associated with MILI in testis. piRNA biogenesis is intact in TEX15-deficient male germ cells.
Title: TEX15 associates with MILI and silences transposable elements in male germ cells.
Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination.
Title: Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.
Tex15 is essential for male meiosis and for chromosomal synapsis. DNA double-strand breaks (DSBs) are formed but not repaired in Tex15-deficient males.
Title: Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tex15 (e-PCR), detects polymorphism
- UniSTS:546571

G65217 (e-PCR)
- UniSTS:225850

RH125316 (e-PCR)
- UniSTS:162138

NoName (e-PCR)
- UniSTS:235868

G65791 (e-PCR)
- UniSTS:225927

AU022940 (e-PCR)
- UniSTS:209045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect DNA methylation-dependent constitutive heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in piRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transposable element silencing by piRNA-mediated DNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: testis-expressed protein 15

Names: testis-expressed sequence 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031374.2 → NP_113551.2 testis-expressed protein 15

See identical proteins and their annotated locations for NP_113551.2

Status: VALIDATED

Source sequence(s)

AC139025, AF285589, BC063106

Consensus CDS

CCDS22232.1

UniProtKB/Swiss-Prot

F8VPN2, Q3UPQ6, Q3V162, Q99MV3

Related

ENSMUSP00000009772.8, ENSMUST00000009772.8

Conserved Domains (1) summary

pfam15326
Location:1574 → 1788

TEX15; Testis expressed sequence 15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

34006712..34082531

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508976.4 → XP_006509039.1 testis-expressed protein 15 isoform X1

See identical proteins and their annotated locations for XP_006509039.1

Conserved Domains (2) summary

pfam12509
Location:104 → 251

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1848 → 2062

TEX15; Testis expressed sequence 15
XM_006508977.4 → XP_006509040.1 testis-expressed protein 15 isoform X1

See identical proteins and their annotated locations for XP_006509040.1

Conserved Domains (2) summary

pfam12509
Location:104 → 251

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1848 → 2062

TEX15; Testis expressed sequence 15
XM_006508975.3 → XP_006509038.1 testis-expressed protein 15 isoform X1

See identical proteins and their annotated locations for XP_006509038.1

Conserved Domains (2) summary

pfam12509
Location:104 → 251

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1848 → 2062

TEX15; Testis expressed sequence 15
XM_011242106.2 → XP_011240408.1 testis-expressed protein 15 isoform X1

See identical proteins and their annotated locations for XP_011240408.1

Conserved Domains (2) summary

pfam12509
Location:104 → 251

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1848 → 2062

TEX15; Testis expressed sequence 15