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    Trmt5 TRM5 tRNA methyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 76357, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Trmt5provided by MGI
    Official Full Name
    TRM5 tRNA methyltransferase 5provided by MGI
    Primary source
    MGI:MGI:1923607
    See related
    Ensembl:ENSMUSG00000034442 AllianceGenome:MGI:1923607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1393; 2610027O18Rik
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in nucleus. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in heart adult (RPKM 3.4), CNS E11.5 (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt5 in Genome Data Viewer
    Location:
    12 C3; 12 30.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (73315289..73333754, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (73268515..73286975, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene menage a trois 1 Neighboring gene STARR-positive B cell enhancer ABC_E7146 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9148 Neighboring gene STARR-seq mESC enhancer starr_32467 Neighboring gene solute carrier family 38, member 6 Neighboring gene STARR-seq mESC enhancer starr_32469 Neighboring gene RIKEN cDNA D830013O20 gene Neighboring gene predicted gene, 40442 Neighboring gene predicted gene, 33929

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Perniss A, et al. Immunity, 2020 Apr 14. PMID 32294408
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
      Title: Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1393

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (guanine(37)-N(1))-methyltransferase; tRNA (guanine(37)-N1)-methyltransferase
    Names
    M1G-methyltransferase
    TRM5 tRNA methyltransferase 5 homolog
    tRNA (guanine-N(1)-)-methyltransferase
    tRNA [GM37] methyltransferase
    tRNA methyltransferase 5 homolog
    NP_001405058.1
    NP_001405059.1
    NP_001405060.1
    NP_001405061.1
    NP_083856.1
    XP_006516420.1
    XP_006516421.1
    XP_017170731.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418129.1 → NP_001405058.1  tRNA (guanine(37)-N(1))-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122025, AC159813

    2. NM_001418130.1 → NP_001405059.1  tRNA (guanine(37)-N(1))-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122025, AC159813

    3. NM_001418131.1 → NP_001405060.1  tRNA (guanine(37)-N(1))-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122025, AC159813

    4. NM_001418132.1 → NP_001405061.1  tRNA (guanine(37)-N(1))-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122025, AC159813

    5. NM_029580.4 → NP_083856.1  tRNA (guanine(37)-N(1))-methyltransferase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122025, AC159813
      Consensus CDS
      CCDS36474.1
      UniProtKB/Swiss-Prot
      Q5DTY1, Q9D0C4
      Related
      ENSMUSP00000112121.3, ENSMUST00000116420.4
      Conserved Domains (2) summary
      COG2520
      Location:90 → 462
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
      pfam12847
      Location:291 → 352
      Methyltransf_18; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      73315289..73333754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516358.4 → XP_006516421.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

      Conserved Domains (1) summary
      COG2520
      Location:38 → 410
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

    2. XM_006516357.3 → XP_006516420.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

      Conserved Domains (1) summary
      COG2520
      Location:38 → 410
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

    3. XM_017315242.3 → XP_017170731.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

      Conserved Domains (1) summary
      COG2520
      Location:38 → 410
      Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_872724.4 RNA Sequence

    2. XR_872723.4 RNA Sequence

    3. XR_004937554.1 RNA Sequence

    4. XR_004937555.1 RNA Sequence

    5. XR_872722.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0C4.1 GenPept UniProtKB/Swiss-Prot:Q9D0C4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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