Tapbp TAP binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tapbpprovided by MGI
Official Full Name: TAP binding proteinprovided by MGI
Primary source: MGI:MGI:1201689
See related: Ensembl:ENSMUSG00000024308 AllianceGenome:MGI:1201689
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TPN; D17Wsu91e
Summary: Predicted to enable several functions, including MHC class I protein complex binding activity; TAP binding activity; and TAP complex binding activity. Involved in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent and peptide antigen stabilization. Acts upstream of or within defense response. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of Tapasin-ERp57 complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; notochord; and retina. Human ortholog(s) of this gene implicated in severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in duodenum adult (RPKM 118.6), mammary gland adult (RPKM 101.7) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.98 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (34138452..34148264)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (33919478..33929290)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication.
Title: Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication.
These results combined with mutation analyses allow us to propose a molecular model underlying MHC-I peptide selection by tapasin.
Title: Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.
Qa-1b-restricted CD8+ T cells display characteristics of both conventional hypervariable T cells as well as invariant T cells and can be classified as semi-invariant T cells, with only conserved Valpha usage, positioned between these two known T cell subsets.
Title: T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1(b) with TAP-Independent Peptides Are Semi-Invariant Lymphocytes.
Absence of Tpn or ERAAP independently altered the peptide repertoire by causing loss as well as gain of new pMHC I. Tpn defined the characteristic carboxy termini of canonical MHC I peptides.
Title: ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.
modification of Tapasin can enhance the presentation of targeting antigens via intracellular delivery to DCs and elicit specific CTL immune responses efficiently
Title: The modification of Tapasin enhances cytotoxic T lymphocyte activity of intracellularly delivered CTL epitopes via cytoplasmic transduction peptide.
Data show that tapasin expression is enhanced by beta 2-microglobulin via both transcriptional and post-transcriptional mechanisms.
Title: Impact of beta 2-microglobulin on tapasin expression and covalent association.
Deletion of a loop within the tapasin C-terminal Ig-like domain (Delta334-342) prevented tapasin association with the MHC class I molecule K(d).
Title: Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.
E2F1 is an essential transcription factor for tapasin.
Title: Identification of E2F1 as an important transcription factor for the regulation of tapasin expression.
showed that a large disulfide-bonded complex was present in the mouse cells that included ERp57, tapasin, and K(d).
Title: Effect of a tapasin mutant on the assembly of the mouse MHC class I molecule H2-K(d).
Tapasin editing is a contributing factor to the phenomenon of immunodominance.
Title: Absence of tapasin alters immunodominance against a lymphocytic choriomeningitis virus polytope.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI415166 (e-PCR)
- UniSTS:181004

UniSTS:237624 (e-PCR)
- UniSTS:237624

Tapbp (e-PCR), detects polymorphism
- UniSTS:463435

Zfp297 (e-PCR), detects polymorphism
- UniSTS:463439

RH125641 (e-PCR)
- UniSTS:142179

AI265210 (e-PCR)
- UniSTS:160652

RH125422 (e-PCR)
- UniSTS:162244

GDB:554881 (e-PCR)
- UniSTS:157662

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MHC class I protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables TAP complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables TAP complex binding	ISO Inferred from Sequence Orthology more info
enables TAP1 binding	ISO Inferred from Sequence Orthology more info
enables TAP2 binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MHC class Ib protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide antigen assembly with MHC class I protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class I protein complex	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of MHC class I peptide loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of Tapasin-ERp57 complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: tapasin

Names: TAP-associated protein; TPSN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.