Ntn5 netrin 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntn5provided by MGI
Official Full Name: netrin 5provided by MGI
Primary source: MGI:MGI:2685330
See related: Ensembl:ENSMUSG00000070564 AllianceGenome:MGI:2685330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm484
Summary: Involved in neurogenesis. Predicted to be located in extracellular region. Predicted to be active in basement membrane. Is expressed in several structures, including olfactory system; spinal component of peripheral nervous system; tail; trigeminal nerve; and vibrissa. Orthologous to human NTN5 (netrin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 6.9), cortex adult (RPKM 4.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.43 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45333519..45343980)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45684022..45694556)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit229 (e-PCR), detects polymorphism
- UniSTS:131122

D7Dcr18 (e-PCR), detects polymorphism
- UniSTS:507774

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: netrin-5

Names: netrin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033356.4 → NP_001028528.2 netrin-5 isoform a precursor

See identical proteins and their annotated locations for NP_001028528.2

Status: VALIDATED

Source sequence(s)

AC167242

Consensus CDS

CCDS39957.1

UniProtKB/Swiss-Prot

B9EKG6, Q3UQ22

Related

ENSMUSP00000103371.2, ENSMUST00000107742.11

Conserved Domains (3) summary

cd00055
Location:227 → 276

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:313 → 438

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

cl02806
Location:78 → 123

Laminin_N; Laminin N-terminal (Domain VI)
NM_001289692.2 → NP_001276621.1 netrin-5 isoform b precursor

Status: VALIDATED

Source sequence(s)

AC167242

Consensus CDS

CCDS80723.1

UniProtKB/TrEMBL

S4R1A5

Related

ENSMUSP00000138144.2, ENSMUST00000183120.4

Conserved Domains (2) summary

cd00055
Location:227 → 276

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cl02806
Location:78 → 123

Laminin_N; Laminin N-terminal (Domain VI)
NM_001289693.2 → NP_001276622.1 netrin-5 isoform c

Status: VALIDATED

Source sequence(s)

AC167242

Consensus CDS

CCDS71964.1

UniProtKB/TrEMBL

S4R1X6

Related

ENSMUSP00000138412.2, ENSMUST00000182750.10

Conserved Domains (2) summary

cd00055
Location:158 → 207

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:244 → 369

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001358870.2 → NP_001345799.1 netrin-5 isoform d precursor

Status: VALIDATED

Source sequence(s)

AC167242

UniProtKB/TrEMBL

A0A140H8W8

Conserved Domains (2) summary

cd00055
Location:290 → 339

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:376 → 501

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

45333519..45343980

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540888.5 → XP_006540951.1 netrin-5 isoform X3

Conserved Domains (2) summary

cd00055
Location:290 → 339

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:366 → 482

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_006540890.5 → XP_006540953.1 netrin-5 isoform X5

Conserved Domains (2) summary

cd00055
Location:227 → 276

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:321 → 446

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_006540885.5 → XP_006540948.1 netrin-5 isoform X1

Conserved Domains (2) summary

cd00055
Location:290 → 339

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:384 → 509

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_036153115.1 → XP_036009008.1 netrin-5 isoform X6

Conserved Domains (2) summary

cd00055
Location:227 → 276

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:295 → 411

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_006540889.5 → XP_006540952.1 netrin-5 isoform X4

Conserved Domains (2) summary

cd00055
Location:290 → 339

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:358 → 474

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_036153116.1 → XP_036009009.1 netrin-5 isoform X7

Conserved Domains (2) summary

cd00055
Location:158 → 207

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:252 → 377

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_006540886.4 → XP_006540949.1 netrin-5 isoform X2

Conserved Domains (2) summary

cd00055
Location:285 → 334

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:379 → 504

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_006540893.5 → XP_006540956.1 netrin-5 isoform X9

Conserved Domains (2) summary

cd00055
Location:153 → 202

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:247 → 372

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
XM_006540892.4 → XP_006540955.1 netrin-5 isoform X8

Conserved Domains (2) summary

cd00055
Location:158 → 207

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:252 → 377

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...