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    Igsf10 immunoglobulin superfamily, member 10 [ Mus musculus (house mouse) ]

    Gene ID: 242050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igsf10provided by MGI
    Official Full Name
    immunoglobulin superfamily, member 10provided by MGI
    Primary source
    MGI:MGI:1923481
    See related
    Ensembl:ENSMUSG00000036334 AllianceGenome:MGI:1923481
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CMF608; Adlican2; 9030224D03; 6530405F15Rik
    Summary
    Involved in regulation of neuron migration. Predicted to be active in extracellular region. Is expressed in branchial arch; embryo mesenchyme; lip; and skeleton. Orthologous to human IGSF10 (immunoglobulin superfamily member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 6.6), subcutaneous fat pad adult (RPKM 3.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Igsf10 in Genome Data Viewer
    Location:
    3 D; 3 29.03 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (59224156..59256836, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59316735..59344438, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12-like Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CMF608-a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. Segev O, et al. Bone, 2004 Feb. PMID 14962803
    2. IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. Howard SR, et al. EMBO Mol Med, 2016 Jun. PMID 27137492, Free PMC Article
    3. Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Homma S, et al. Gene Expr Patterns, 2009 Jan. PMID 18848646
    4. Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. Gu Z, et al. PLoS One, 2015. PMID 25826454, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 10

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162884.1 → NP_001156356.1  immunoglobulin superfamily member 10 precursor

      See identical proteins and their annotated locations for NP_001156356.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122038, AC135238
      Consensus CDS
      CCDS50915.1
      UniProtKB/Swiss-Prot
      Q3UPM4, Q3V1M1
      Related
      ENSMUSP00000037246.7, ENSMUST00000039419.12
      Conserved Domains (11) summary
      smart00013
      Location:29 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 276
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2506 → 2593
      IG; Immunoglobulin
      smart00410
      Location:583 → 662
      IG_like; Immunoglobulin like
      COG4886
      Location:152 → 402
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1637 → 1708
      Ig; Immunoglobulin domain
      pfam13855
      Location:82 → 141
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2120 → 2199
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2403 → 2481
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:187 → 220
      LRR_4; Leucine Rich repeats (2 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      59224156..59256836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252616.2 → XP_030108476.1  immunoglobulin superfamily member 10 isoform X3

      Conserved Domains (6) summary
      smart00409
      Location:325 → 404
      IG; Immunoglobulin
      smart00410
      Location:1466 → 1550
      IG_like; Immunoglobulin like
      pfam07679
      Location:1862 → 1941
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1654 → 1733
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1669 → 1679
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1363 → 1453
      Ig; Immunoglobulin domain

    2. XM_006501468.5 → XP_006501531.1  immunoglobulin superfamily member 10 isoform X2

      Conserved Domains (10) summary
      smart00082
      Location:133 → 190
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:497 → 576
      IG; Immunoglobulin
      smart00410
      Location:2420 → 2507
      IG_like; Immunoglobulin like
      COG4886
      Location:66 → 316
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:21 → 44
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1551 → 1622
      Ig; Immunoglobulin domain
      pfam13855
      Location:1 → 55
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2034 → 2113
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2317 → 2395
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:101 → 134
      LRR_4; Leucine Rich repeats (2 copies)

    3. XM_006501467.5 → XP_006501530.1  immunoglobulin superfamily member 10 isoform X1

      See identical proteins and their annotated locations for XP_006501530.1

      UniProtKB/Swiss-Prot
      Q3UPM4, Q3V1M1
      Related
      ENSMUSP00000141391.2, ENSMUST00000194546.6
      Conserved Domains (11) summary
      smart00013
      Location:29 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 276
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2506 → 2593
      IG; Immunoglobulin
      smart00410
      Location:583 → 662
      IG_like; Immunoglobulin like
      COG4886
      Location:152 → 402
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1637 → 1708
      Ig; Immunoglobulin domain
      pfam13855
      Location:82 → 141
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2120 → 2199
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2403 → 2481
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:187 → 220
      LRR_4; Leucine Rich repeats (2 copies)

    4. XM_030252615.2 → XP_030108475.1  immunoglobulin superfamily member 10 isoform X2

      Conserved Domains (10) summary
      smart00082
      Location:133 → 190
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:497 → 576
      IG; Immunoglobulin
      smart00410
      Location:2420 → 2507
      IG_like; Immunoglobulin like
      COG4886
      Location:66 → 316
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:21 → 44
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1551 → 1622
      Ig; Immunoglobulin domain
      pfam13855
      Location:1 → 55
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2034 → 2113
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2317 → 2395
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:101 → 134
      LRR_4; Leucine Rich repeats (2 copies)

    5. XM_036163101.1 → XP_036018994.1  immunoglobulin superfamily member 10 isoform X3

      Conserved Domains (6) summary
      smart00409
      Location:325 → 404
      IG; Immunoglobulin
      smart00410
      Location:1466 → 1550
      IG_like; Immunoglobulin like
      pfam07679
      Location:1862 → 1941
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1654 → 1733
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1669 → 1679
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1363 → 1453
      Ig; Immunoglobulin domain

    6. XM_011240117.4 → XP_011238419.1  immunoglobulin superfamily member 10 isoform X1

      See identical proteins and their annotated locations for XP_011238419.1

      UniProtKB/Swiss-Prot
      Q3UPM4, Q3V1M1
      Conserved Domains (11) summary
      smart00013
      Location:29 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 276
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2506 → 2593
      IG; Immunoglobulin
      smart00410
      Location:583 → 662
      IG_like; Immunoglobulin like
      COG4886
      Location:152 → 402
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1637 → 1708
      Ig; Immunoglobulin domain
      pfam13855
      Location:82 → 141
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2120 → 2199
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2403 → 2481
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:187 → 220
      LRR_4; Leucine Rich repeats (2 copies)

    7. XM_036163100.1 → XP_036018993.1  immunoglobulin superfamily member 10 isoform X3

      Conserved Domains (6) summary
      smart00409
      Location:325 → 404
      IG; Immunoglobulin
      smart00410
      Location:1466 → 1550
      IG_like; Immunoglobulin like
      pfam07679
      Location:1862 → 1941
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1654 → 1733
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1669 → 1679
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1363 → 1453
      Ig; Immunoglobulin domain

    8. XM_006501465.5 → XP_006501528.1  immunoglobulin superfamily member 10 isoform X1

      See identical proteins and their annotated locations for XP_006501528.1

      UniProtKB/Swiss-Prot
      Q3UPM4, Q3V1M1
      Conserved Domains (11) summary
      smart00013
      Location:29 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 276
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2506 → 2593
      IG; Immunoglobulin
      smart00410
      Location:583 → 662
      IG_like; Immunoglobulin like
      COG4886
      Location:152 → 402
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1637 → 1708
      Ig; Immunoglobulin domain
      pfam13855
      Location:82 → 141
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2120 → 2199
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2403 → 2481
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:187 → 220
      LRR_4; Leucine Rich repeats (2 copies)

    9. XM_006501466.5 → XP_006501529.1  immunoglobulin superfamily member 10 isoform X1

      See identical proteins and their annotated locations for XP_006501529.1

      UniProtKB/Swiss-Prot
      Q3UPM4, Q3V1M1
      Related
      ENSMUSP00000141971.2, ENSMUST00000193455.6
      Conserved Domains (11) summary
      smart00013
      Location:29 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 276
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2506 → 2593
      IG; Immunoglobulin
      smart00410
      Location:583 → 662
      IG_like; Immunoglobulin like
      COG4886
      Location:152 → 402
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      cd00096
      Location:1637 → 1708
      Ig; Immunoglobulin domain
      pfam13855
      Location:82 → 141
      LRR_8; Leucine rich repeat
      pfam07679
      Location:2120 → 2199
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:2403 → 2481
      Ig_3; Immunoglobulin domain
      pfam12799
      Location:187 → 220
      LRR_4; Leucine Rich repeats (2 copies)

    10. XM_036163102.1 → XP_036018995.1  immunoglobulin superfamily member 10 isoform X3

      Conserved Domains (6) summary
      smart00409
      Location:325 → 404
      IG; Immunoglobulin
      smart00410
      Location:1466 → 1550
      IG_like; Immunoglobulin like
      pfam07679
      Location:1862 → 1941
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:1654 → 1733
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1669 → 1679
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1363 → 1453
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V1M1.2 GenPept UniProtKB/Swiss-Prot:Q3V1M1

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