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    Hspd1 heat shock protein 1 (chaperonin) [ Mus musculus (house mouse) ]

    Gene ID: 15510, updated on 4-Jan-2025

    Summary

    Official Symbol
    Hspd1provided by MGI
    Official Full Name
    heat shock protein 1 (chaperonin)provided by MGI
    Primary source
    MGI:MGI:96242
    See related
    Ensembl:ENSMUSG00000025980 AllianceGenome:MGI:96242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    60kDa; CPN60; Hsp60; HSP-60; HSP-65
    Summary
    Enables lipopolysaccharide binding activity. Involved in positive regulation of T cell activation and positive regulation of type II interferon production. Acts upstream of or within T cell activation; cellular response to interleukin-7; and positive regulation of interferon-alpha production. Located in migrasome; secretory granule; and sperm plasma membrane. Is active in mitochondrion. Is expressed in several structures, including brain; eye; heart; and urinary system. Used to study hereditary spastic paraplegia 13. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in placenta adult (RPKM 119.5), liver E14 (RPKM 114.0) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Hspd1 in Genome Data Viewer
    Location:
    1 C1.2; 1 28.01 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (55116992..55127402, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (55077833..55088243, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_00942 Neighboring gene STARR-seq mESC enhancer starr_00943 Neighboring gene coenzyme Q10B Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7728 Neighboring gene heat shock protein 1 (chaperonin 10) Neighboring gene STARR-seq mESC enhancer starr_00944 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene serine/arginine repetitive matrix 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP-dependent protein folding chaperone  
    enables apolipoprotein A-I binding  
    enables apolipoprotein A-I binding  
    enables apolipoprotein binding  
    enables double-stranded RNA binding PubMed 
    enables enzyme binding  
    enables high-density lipoprotein particle binding  
    enables high-density lipoprotein particle binding  
    enables isomerase activity  
    enables lipopolysaccharide binding PubMed 
    enables lipopolysaccharide binding  
    enables modification-dependent protein binding  
    enables p53 binding  
    enables p53 binding  
    enables protein-containing complex binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 62
    Process Evidence Code Pubs
    involved_in B cell activation  
    involved_in B cell proliferation  
    involved_in B cell proliferation  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    involved_in T cell activation  
    acts_upstream_of_or_within T cell activation PubMed 
    acts_upstream_of_or_within T cell activation PubMed 
    acts_upstream_of_or_within T cell activation  
    NOT involved_in adhesion of symbiont to host PubMed 
    involved_in apoptotic mitochondrial changes  
    involved_in apoptotic mitochondrial changes  
    involved_in biological process involved in interaction with symbiont  
    involved_in biological process involved in interaction with symbiont  
    acts_upstream_of_or_within cellular response to interleukin-7 PubMed 
    acts_upstream_of interferon-alpha production PubMed 
    involved_in isotype switching to IgG isotypes  
    involved_in isotype switching to IgG isotypes  
    involved_in mitochondrial unfolded protein response  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process in bone marrow cell  
    involved_in negative regulation of neuron apoptotic process  
    involved_in negative regulation of reactive oxygen species biosynthetic process  
    involved_in positive regulation of T cell activation  
    involved_in positive regulation of T cell activation PubMed 
    involved_in positive regulation of T cell activation  
    involved_in positive regulation of T cell mediated immune response to tumor cell  
    involved_in positive regulation of T cell mediated immune response to tumor cell  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of interferon-alpha production  
    acts_upstream_of_or_within positive regulation of interferon-alpha production PubMed 
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type II interferon production  
    acts_upstream_of_or_within positive regulation of type II interferon production PubMed 
    involved_in positive regulation of type II interferon production PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production PubMed 
    acts_upstream_of_or_within positive regulation of type II interferon production  
    involved_in positive regulation of type II interferon production  
    involved_in protein folding  
    involved_in protein import into mitochondrial intermembrane space  
    involved_in protein refolding  
    involved_in protein refolding  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in response to cold  
    involved_in response to unfolded protein  
    involved_in response to unfolded protein  
    acts_upstream_of type II interferon production PubMed 
    acts_upstream_of type II interferon production PubMed 
    Items 1 - 25 of 62
    Items 1 - 20 of 43
    Component Evidence Code Pubs
    located_in Golgi cisterna  
    located_in cell surface  
    located_in cell surface  
    located_in clathrin-coated pit  
    located_in clathrin-coated pit  
    located_in coated vesicle  
    located_in coated vesicle  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in early endosome  
    located_in early endosome  
    located_in extracellular exosome  
    located_in extracellular exosome  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle PubMed 
    part_of lipopolysaccharide receptor complex  
    part_of lipopolysaccharide receptor complex  
    located_in membrane PubMed 
    located_in migrasome PubMed 
    located_in mitochondrial crista  
    located_in mitochondrial inner membrane PubMed 
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in myelin sheath PubMed 
    located_in peroxisomal matrix  
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in secretory granule PubMed 
    located_in secretory granule  
    located_in sperm midpiece  
    located_in sperm plasma membrane PubMed 
    located_in zymogen granule  
    Items 1 - 20 of 43

    General protein information

    Preferred Names
    60 kDa heat shock protein, mitochondrial
    Names
    60 kDa chaperonin
    chaperonin 60
    heat shock 60kDa protein 1 (chaperonin)
    heat shock protein 60
    heat shock protein, 60 kDa
    mitochondrial matrix protein P1
    NP_001343441.1
    NP_034607.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356512.1NP_001343441.1  60 kDa heat shock protein, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AC108391
      Consensus CDS
      CCDS35569.1
      UniProtKB/Swiss-Prot
      P19226, P19227, P63038, P97602, Q3KQP2, Q3UIP0, Q8C2C7, Q8VEF4
      Conserved Domains (1) summary
      cd03344
      Location:28548
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
    2. NM_010477.4NP_034607.3  60 kDa heat shock protein, mitochondrial

      See identical proteins and their annotated locations for NP_034607.3

      Status: VALIDATED

      Source sequence(s)
      AK143882, BF607107, BY014148
      Consensus CDS
      CCDS35569.1
      UniProtKB/Swiss-Prot
      P19226, P19227, P63038, P97602, Q3KQP2, Q3UIP0, Q8C2C7, Q8VEF4
      Related
      ENSMUSP00000027123.9, ENSMUST00000027123.15
      Conserved Domains (1) summary
      cd03344
      Location:28548
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      55116992..55127402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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