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    Arhgap10 Rho GTPase activating protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 78514, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arhgap10provided by MGI
    Official Full Name
    Rho GTPase activating protein 10provided by MGI
    Primary source
    MGI:MGI:1925764
    See related
    Ensembl:ENSMUSG00000037148 AllianceGenome:MGI:1925764
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSGAP; PS-GAP; PSGAP-m; PSGAP-s; A930033B01Rik
    Summary
    Enables GTPase activator activity. Involved in negative regulation of apoptotic process. Acts upstream of or within cytoskeleton organization. Located in cytosol. Is expressed in brain. Orthologous to human ARHGAP10 (Rho GTPase activating protein 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.3), bladder adult (RPKM 9.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap10 in Genome Data Viewer
    Location:
    8 C1; 8 36.6 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (77976995..78244628, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (77250366..77517999, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 3, group C, member 2 Neighboring gene predicted gene, 24838 Neighboring gene predicted gene, 23260 Neighboring gene STARR-seq mESC enhancer starr_21951 Neighboring gene STARR-seq mESC enhancer starr_21952 Neighboring gene STARR-seq mESC enhancer starr_21953 Neighboring gene predicted gene 45407 Neighboring gene STARR-seq mESC enhancer starr_21954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:79946917-79947070 Neighboring gene RIKEN cDNA 0610038B21 gene Neighboring gene STARR-seq mESC enhancer starr_21957 Neighboring gene STARR-positive B cell enhancer ABC_E9317 Neighboring gene STARR-positive B cell enhancer ABC_E8249 Neighboring gene STARR-seq mESC enhancer starr_21958 Neighboring gene STARR-positive B cell enhancer ABC_E1761 Neighboring gene protein arginine methyltransferase 9 Neighboring gene transmembrane protein 184C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Sekiguchi M, et al. Transl Psychiatry, 2020 Jul 22. PMID 32699248, Free PMC Article
    2. ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells. Luo N, et al. Cell Death Dis, 2016 Mar 24. PMID 27010858, Free PMC Article
    3. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. Koeppel MA, et al. J Biol Chem, 2004 Dec 17. PMID 15471851
    4. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Hada K, et al. Mol Brain, 2021 Jan 22. PMID 33482876, Free PMC Article
    5. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. Ren XR, et al. J Cell Biol, 2001 Mar 5. PMID 11238453, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
      Title: Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
    2. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways.
      Title: ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (6)  1 citation
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 10
    Names
    PH and SH3 domain-containing rhoGAP protein
    rho-type GTPase-activating protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363417.1 → NP_001350346.1  rho GTPase-activating protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Consensus CDS
      CCDS90420.1
      Related
      ENSMUSP00000147493.2, ENSMUST00000210519.2
      Conserved Domains (5) summary
      cd12065
      Location:710 → 763
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:367 → 547
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:553 → 699
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. NM_001363418.1 → NP_001350347.1  rho GTPase-activating protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Consensus CDS
      CCDS90421.1
      Related
      ENSMUSP00000147485.2, ENSMUST00000210922.2
      Conserved Domains (4) summary
      cd12065
      Location:681 → 734
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367 → 569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001363419.1 → NP_001350348.1  rho GTPase-activating protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (5) summary
      cd12065
      Location:629 → 682
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      NF033913
      Location:518 → 616
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. NM_001363420.1 → NP_001350349.1  rho GTPase-activating protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (5) summary
      cd12065
      Location:607 → 660
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:264 → 444
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl25496
      Location:450 → 596
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    5. NM_001363421.1 → NP_001350350.1  rho GTPase-activating protein 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248
      Conserved Domains (4) summary
      cd12065
      Location:578 → 631
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264 → 466
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. NM_030113.2 → NP_084389.2  rho GTPase-activating protein 10 isoform 1

      See identical proteins and their annotated locations for NP_084389.2

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248, AK041867, BI736055, BU151977, CF106470, CN703944, CV783737
      Consensus CDS
      CCDS22425.1
      UniProtKB/Swiss-Prot
      Q6Y5D6, Q6Y5D7, Q6Y5D8, Q99MT3, Q99MT4
      Related
      ENSMUSP00000075658.5, ENSMUST00000076316.6
      Conserved Domains (5) summary
      cd12065
      Location:732 → 785
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:367 → 569
      RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam00169
      Location:269 → 367
      PH; PH domain
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_156496.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109139, AC119248

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      77976995..78244628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154381.1 → XP_036010274.1  rho GTPase-activating protein 10 isoform X4

      Conserved Domains (5) summary
      cd12065
      Location:660 → 713
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:295 → 497
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:195 → 300
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      NF033913
      Location:549 → 647
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl12013
      Location:19 → 177
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_017313016.2 → XP_017168505.1  rho GTPase-activating protein 10 isoform X2

      Conserved Domains (5) summary
      cd12065
      Location:707 → 760
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam17061
      Location:550 → 696
      PARM
      cl02570
      Location:367 → 544
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_017313015.3 → XP_017168504.1  rho GTPase-activating protein 10 isoform X1

      Conserved Domains (5) summary
      cd12065
      Location:708 → 761
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:343 → 545
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:243 → 348
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam17061
      Location:551 → 697
      PARM
      cl12013
      Location:19 → 201
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_011248553.4 → XP_011246855.1  rho GTPase-activating protein 10 isoform X3

      Conserved Domains (5) summary
      cd12065
      Location:688 → 741
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:323 → 525
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:223 → 328
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam17061
      Location:531 → 677
      PARM
      cl12013
      Location:9 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_036154382.1 → XP_036010275.1  rho GTPase-activating protein 10 isoform X5

      Conserved Domains (5) summary
      cd12065
      Location:629 → 682
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:264 → 466
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      NF033913
      Location:518 → 616
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_017313020.3 → XP_017168509.1  rho GTPase-activating protein 10 isoform X7

      Conserved Domains (5) summary
      cd12065
      Location:604 → 657
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd01249
      Location:164 → 269
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam17061
      Location:447 → 593
      PARM
      cl02570
      Location:264 → 441
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:1 → 122
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_017313019.2 → XP_017168508.1  rho GTPase-activating protein 10 isoform X6

      Conserved Domains (5) summary
      cd12065
      Location:605 → 658
      SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
      cd04374
      Location:240 → 442
      RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
      cd01249
      Location:140 → 245
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      pfam17061
      Location:448 → 594
      PARM
      cl12013
      Location:2 → 98
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    8. XM_017313022.2 → XP_017168511.1  rho GTPase-activating protein 10 isoform X8

      Conserved Domains (3) summary
      cd01249
      Location:267 → 372
      BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
      cl02570
      Location:367 → 399
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
      cl12013
      Location:19 → 225
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001778487.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6Y5D8.2 GenPept UniProtKB/Swiss-Prot:Q6Y5D8

    Gene LinkOut

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