Cep55 centrosomal protein 55 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep55provided by MGI
Official Full Name: centrosomal protein 55provided by MGI
Primary source: MGI:MGI:1921357
See related: Ensembl:ENSMUSG00000024989 AllianceGenome:MGI:1921357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200008O12Rik; 2700032M20Rik
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Located in intercellular bridge and midbody. Is expressed in cerebral cortex ventricular layer; germ cell of testis; and ovary. Used to study Meckel syndrome. Human ortholog(s) of this gene implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. Orthologous to human CEP55 (centrosomal protein 55). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 14.2), placenta adult (RPKM 6.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C2; 19 32.69 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (38043423..38062873)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (38054970..38074425)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
Title: Hsa-miR-195-5p Inhibits Autophagy and Gemcitabine Resistance of Lung Adenocarcinoma Cells via E2F7/CEP55.
alpha-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.
Title: α-catenin interaction with YAP/FoxM1/TEAD-induced CEP55 supports liver cancer cell migration.
MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.
Title: MicroRNA-449a Suppresses Mouse Spermatogonia Proliferation via Inhibition of CEP55.
CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
Title: CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
Title: Loss of Coiled-Coil Protein Cep55 Impairs Neural Stem Cell Abscission and Results in p53-Dependent Apoptosis in Developing Cortex.
Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
Title: Cep55 overexpression promotes genomic instability and tumorigenesis in mice.
This work defines Cep55 as an abscission regulator.
Title: Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Study found that Cep55-depleted mouse oocytes progress normally through early meiosis I, but that anaphase I fails as a result of persistent Cdk1 activity.
Title: First meiotic anaphase requires Cep55-dependent inhibitory cyclin-dependent kinase 1 phosphorylation.
that Cep55 overexpression causes change in germ cell proportions and manifests as a Sertoli cell only tubule phenotype
Title: Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of PI3K/Akt signaling.
Cep55 may act as an MTOC-associated protein regulating spindle organization, and thus cell cycle progression during mouse oocyte meiotic maturation.
Title: Cep55 regulates spindle organization and cell cycle progression in meiotic oocyte.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cep55 (e-PCR), detects polymorphism
- UniSTS:527285

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cranial skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in midbody abscission	IEA Inferred from Electronic Annotation more info
involved_in midbody abscission	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
located_in Flemming body	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IDA Inferred from Direct Assay more info	PubMed
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 55 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164362.2 → NP_001157834.1 centrosomal protein of 55 kDa isoform 1

See identical proteins and their annotated locations for NP_001157834.1

Status: VALIDATED

Source sequence(s)

AC101774, AK004655, AW538141

Consensus CDS

CCDS50429.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Related

ENSMUSP00000127961.2, ENSMUST00000169673.3

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
NM_001360663.1 → NP_001347592.1 centrosomal protein of 55 kDa isoform 1

Status: VALIDATED

Source sequence(s)

AC101774

Consensus CDS

CCDS50429.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Related

ENSMUSP00000157898.2, ENSMUST00000236044.2

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
NM_028293.2 → NP_082569.1 centrosomal protein of 55 kDa isoform 1

See identical proteins and their annotated locations for NP_082569.1

Status: VALIDATED

Source sequence(s)

AC101774, AK004655, AK028216, AW538141, CJ074252

Consensus CDS

CCDS50429.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Related

ENSMUSP00000093802.5, ENSMUST00000096096.12

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
NM_028760.3 → NP_083036.2 centrosomal protein of 55 kDa isoform 2

Status: VALIDATED

Source sequence(s)

AC101774, AK004655, AW538141

Consensus CDS

CCDS29782.1

UniProtKB/Swiss-Prot

Q8BT07

Related

ENSMUSP00000157871.2, ENSMUST00000237408.2

Conserved Domains (2) summary

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55

cl19219
Location:256 → 332

DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

38043423..38062873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527396.3 → XP_006527459.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006527459.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_006527399.4 → XP_006527462.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006527462.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_006527401.2 → XP_006527464.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006527464.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_030251115.2 → XP_030106975.1 centrosomal protein of 55 kDa isoform X2

Conserved Domains (2) summary

COG1196
Location:78 → 244

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:17 → 50

EABR; TSG101 and ALIX binding domain of CEP55
XM_006527402.3 → XP_006527465.1 centrosomal protein of 55 kDa isoform X2

Conserved Domains (2) summary

COG1196
Location:78 → 244

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:17 → 50

EABR; TSG101 and ALIX binding domain of CEP55
XM_030251114.2 → XP_030106974.1 centrosomal protein of 55 kDa isoform X2

Conserved Domains (2) summary

COG1196
Location:78 → 244

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:17 → 50

EABR; TSG101 and ALIX binding domain of CEP55
XM_006527397.5 → XP_006527460.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006527460.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_011247381.4 → XP_011245683.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_011245683.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_006527398.5 → XP_006527461.1 centrosomal protein of 55 kDa isoform X1

See identical proteins and their annotated locations for XP_006527461.1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_036161710.1 → XP_036017603.1 centrosomal protein of 55 kDa isoform X1

UniProtKB/Swiss-Prot

Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8

Conserved Domains (2) summary

COG1196
Location:58 → 397

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:171 → 204

EABR; TSG101 and ALIX binding domain of CEP55
XM_036161711.1 → XP_036017604.1 centrosomal protein of 55 kDa isoform X2

Conserved Domains (2) summary

COG1196
Location:78 → 244

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:17 → 50

EABR; TSG101 and ALIX binding domain of CEP55
XM_030251113.2 → XP_030106973.1 centrosomal protein of 55 kDa isoform X2

Conserved Domains (2) summary

COG1196
Location:78 → 244

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:17 → 50

EABR; TSG101 and ALIX binding domain of CEP55
XM_036161712.1 → XP_036017605.1 centrosomal protein of 55 kDa isoform X2

Conserved Domains (2) summary

COG1196
Location:78 → 244

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12180
Location:17 → 50

EABR; TSG101 and ALIX binding domain of CEP55