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    act1 actin Act1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540051, updated on 18-Sep-2024

    Summary

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    Official Symbol
    act1
    Official Full Name
    actin Act1
    Primary source
    PomBase:SPBC32H8.12c
    Locus tag
    SPOM_SPBC32H8.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cps8
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    Genomic context

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    See act1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1475485..1477333, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-binding forkhead transcription factor, meiotic Mei4 Neighboring gene ncRNA Neighboring gene spore wall alpha-1,3-glucan synthase Mok12 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ultrastructure of cell wall of the cps8 actin mutant cell in Schizosaccharomyces pombe. Ishijima SA, et al. FEMS Microbiol Lett, 1999 Nov 1. PMID 10547441
    2. The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. Balasubramanian MK, et al. J Cell Biol, 1994 Jun. PMID 8207058, Free PMC Article
    3. Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis. Ueda EI, et al. Biochem Biophys Res Commun, 2018 Nov 25. PMID 30201262
    4. A molecular evolution approach to study the roles of tropomyosin in fission yeast. Cranz-Mileva S, et al. PLoS One, 2013. PMID 24167549, Free PMC Article
    5. Overproduction of elongation factor 1alpha, an essential translational component, causes aberrant cell morphology by affecting the control of growth polarity in fission yeast. Suda M, et al. Genes Cells, 1999 Sep. PMID 10526238

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.
      Title: Fission yeast Adf1 is necessary for reassembly of actin filaments into the contractile ring during cytokinesis.
    2. Furthermore, Cdc8, Fim1, and Adf1 all compete for association with F-actin by different mechanisms, and their cooperative association with actin filaments affects their ability to compete.
      Title: Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
    3. Data indicate that the essential role of profilin is to specifically facilitate formin Cdc12-mediated actin assembly for cytokinesis.
      Title: Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Ino80 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Ino80 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, distal actin filament layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, intermediate layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic actomyosin contractile ring, proximal layer IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin Act1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1475485..1477333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021513.3 → NP_595618.1  actin Act1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595618.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P10989, Q10288
      Conserved Domains (2) summary
      smart00268
      Location:6 → 375
      ACTIN; Actin
      cl17037
      Location:1 → 375
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version

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