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    Hoxa4 homeobox A4 [ Mus musculus (house mouse) ]

    Gene ID: 15401, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hoxa4provided by MGI
    Official Full Name
    homeobox A4provided by MGI
    Primary source
    MGI:MGI:96176
    See related
    Ensembl:ENSMUSG00000000942 AllianceGenome:MGI:96176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hox-1.4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification and embryonic skeletal system morphogenesis. Predicted to be located in nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including embryo mesenchyme; gut; nervous system; respiratory system; and skin. Orthologous to human HOXA4 (homeobox A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 27.4), CNS E14 (RPKM 3.8) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Hoxa4 in Genome Data Viewer
    Location:
    6 B3; 6 25.4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52166662..52168683, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52189682..52191703, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene homeobox A3 Neighboring gene predicted gene 15050 Neighboring gene RIKEN cDNA 5730596B20 gene Neighboring gene predicted gene, 57749 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeobox A5 Neighboring gene homeobox A6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Clone Names

    • MGC130055

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nuclear body  
    is_active_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    homeobox protein Hox-A4
    Names
    homeo box A4
    homeobox protein Hox-1.4
    homeobox protein MH-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008265.4NP_032291.1  homeobox protein Hox-A4

      See identical proteins and their annotated locations for NP_032291.1

      Status: VALIDATED

      Source sequence(s)
      AK076098, BQ176943
      Consensus CDS
      CCDS20142.1
      UniProtKB/Swiss-Prot
      P06798, Q61684, Q64388, Q8BPE6
      UniProtKB/TrEMBL
      A0A0R4J193
      Related
      ENSMUSP00000098943.3, ENSMUST00000101395.3
      Conserved Domains (1) summary
      pfam00046
      Location:183236
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52166662..52168683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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