Stxbp4 syntaxin binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stxbp4provided by MGI
Official Full Name: syntaxin binding protein 4provided by MGI
Primary source: MGI:MGI:1342296
See related: Ensembl:ENSMUSG00000020546 AllianceGenome:MGI:1342296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Synip; 6030470M02Rik
Summary: Predicted to enable syntaxin binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; insulin receptor signaling pathway; and regulation of D-glucose transmembrane transport. Located in phagocytic vesicle. Orthologous to human STXBP4 (syntaxin binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 1.5), limb E14.5 (RPKM 1.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 55.04 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (90367318..90528962, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (90476492..90638136, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Syntaxin-4 directly binds to E-cadherin and activates part of Smad signals, leading to the disruption of epithelial intercellular adhesion and an augmented expression of fibroblast markers. These findings highlight the importance of local membrane translocation of syntaxin-4 for spatial epithelial-mesenchymal transition in the epithelia and provide new mechanistic insights into asymmetric epithelial morphogenesis.
Title: Membrane-tethered syntaxin-4 locally abrogates E-cadherin function and activates Smad signals, contributing to asymmetric mammary epithelial morphogenesis.
Serine 99 phosphorylation of Synip is required for Glut4 translocation and glucose uptake in both adipocytes and podocytes.
Title: Synip phosphorylation is required for insulin-stimulated Glut4 translocation and glucose uptake in podocyte.
synip binding did not prevent the pairing of syntaxin-4 with SNAP-23 to form the binary t-SNARE complex
Title: Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor.
By altering the levels of individual components of the VAMP3/Stx4/SNAP23 complex we show here that this SNARE complex regulates efficient macrophage adhesion, spreading and migration on fibronectin.
Title: VAMP3 regulates podosome organisation in macrophages and together with Stx4/SNAP23 mediates adhesion, cell spreading and persistent migration.
Syntaxin 4-based SNARE complexes are essential for biphasic insulin granule fusion in pancreatic beta-cells.
Title: Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ha3011 (e-PCR)
- UniSTS:515625

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH138307 (e-PCR)
- UniSTS:220394

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell cycle G1/S phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein targeting	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: syntaxin-binding protein 4

Names: STX4-interacting protein; syntaxin 4-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011505.3 → NP_035635.1 syntaxin-binding protein 4

See identical proteins and their annotated locations for NP_035635.1

Status: VALIDATED

Source sequence(s)

AL646046

Consensus CDS

CCDS25242.1

UniProtKB/Swiss-Prot

Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1, Q9WV89

Related

ENSMUSP00000116191.2, ENSMUST00000143203.8

Conserved Domains (3) summary

cd00992
Location:21 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:502 → 531

WW; WW domain

pfam08467
Location:189 → 393

Luteo_P1-P2; Luteovirus RNA polymerase P1-P2/replicase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

90367318..90528962 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245750.2 → XP_030101610.1 syntaxin-binding protein 4 isoform X6

Conserved Domains (2) summary

TIGR02169
Location:75 → 240

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam00397
Location:277 → 306

WW; WW domain
XM_006532736.5 → XP_006532799.1 syntaxin-binding protein 4 isoform X1

Related

ENSMUSP00000020858.8, ENSMUST00000020858.14

Conserved Domains (2) summary

cd00992
Location:21 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02169
Location:300 → 465

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006532738.5 → XP_006532801.1 syntaxin-binding protein 4 isoform X3

Conserved Domains (2) summary

cd00992
Location:21 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02169
Location:300 → 465

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006532737.5 → XP_006532800.1 syntaxin-binding protein 4 isoform X2

Conserved Domains (2) summary

cd00992
Location:21 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02169
Location:300 → 465

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
XM_006532739.5 → XP_006532802.1 syntaxin-binding protein 4 isoform X4

Conserved Domains (1) summary

cd00992
Location:21 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_006532740.5 → XP_006532803.1 syntaxin-binding protein 4 isoform X5

Conserved Domains (1) summary

cd00992
Location:21 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...