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    Dnah5 dynein, axonemal, heavy chain 5 [ Mus musculus (house mouse) ]

    Gene ID: 110082, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dnah5provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 5provided by MGI
    Primary source
    MGI:MGI:107718
    See related
    Ensembl:ENSMUSG00000022262 AllianceGenome:MGI:107718
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnahc5; Mdnah5; b2b601Clo; mKIAA1603; b2b1134Clo; b2b1154Clo; b2b1537Clo; b2b1565Clo; b2b3491Clo
    Summary
    Enables microtubule motor activity. Acts upstream of or within several processes, including determination of left/right symmetry; epithelial cilium movement involved in extracellular fluid movement; and lateral ventricle development. Located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Part of outer dynein arm. Is expressed in several structures, including epithelium; gut; male reproductive gland or organ; and midbrain. Used to study otitis media; primary ciliary dyskinesia (multiple); tetralogy of Fallot; and visceral heterotaxy. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Dnah5 in Genome Data Viewer
    Location:
    15 B1; 15 10.9 cM
    Exon count:
    80
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (28155000..28472191)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (28154854..28472045)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38244 Neighboring gene predicted gene, 31458 Neighboring gene ribosomal protein L35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38247 Neighboring gene STARR-seq mESC enhancer starr_38248 Neighboring gene STARR-seq mESC enhancer starr_38249 Neighboring gene STARR-seq mESC enhancer starr_38250 Neighboring gene deleted in bladder cancer 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38251 Neighboring gene predicted gene, 31687

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (14)  1 citation
    • Endonuclease-mediated (1) 
    • Spontaneous (1) 
    • Targeted (2) 
    • Transgenic (1)  1 citation

    Interactions

    General gene information

    Clone Names

    • KIAA1603

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables dynein intermediate chain binding  
    enables dynein intermediate chain binding  
    enables dynein light intermediate chain binding  
    enables dynein light intermediate chain binding  
    enables microtubule motor activity PubMed 
    enables minus-end-directed microtubule motor activity  
    enables minus-end-directed microtubule motor activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium assembly  
    acts_upstream_of_or_within cilium movement PubMed 
    acts_upstream_of_or_within cilium movement  
    involved_in cilium movement involved in cell motility  
    acts_upstream_of_or_within determination of left/right symmetry PubMed 
    acts_upstream_of_or_within determination of left/right symmetry  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement PubMed 
    acts_upstream_of_or_within establishment of localization in cell PubMed 
    involved_in flagellated sperm motility  
    acts_upstream_of_or_within flagellated sperm motility  
    acts_upstream_of_or_within heart development PubMed 
    acts_upstream_of_or_within lateral ventricle development PubMed 
    involved_in outer dynein arm assembly  
    involved_in outer dynein arm assembly  
    acts_upstream_of_or_within outer dynein arm assembly  
    Component Evidence Code Pubs
    located_in 9+0 motile cilium PubMed 
    is_active_in 9+2 motile cilium  
    located_in 9+2 motile cilium PubMed 
    part_of axonemal dynein complex PubMed 
    located_in axoneme PubMed 
    located_in axoneme PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in extracellular region  
    located_in glial cell projection PubMed 
    located_in microtubule  
    located_in motile cilium  
    located_in motile cilium  
    part_of outer dynein arm  
    part_of outer dynein arm PubMed 
    part_of outer dynein arm  

    General protein information

    Preferred Names
    dynein axonemal heavy chain 5
    Names
    axonemal beta dynein heavy chain 5
    axonemal dynein heavy chain 5
    ciliary dynein heavy chain 5
    dynein heavy chain 5, axonemal
    dynein, axon, heavy chain 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133365.3NP_579943.3  dynein axonemal heavy chain 5

      See identical proteins and their annotated locations for NP_579943.3

      Status: VALIDATED

      Source sequence(s)
      AC131997, AC154880
      Consensus CDS
      CCDS27404.1
      UniProtKB/Swiss-Prot
      E9QKD7, Q8BWG1, Q8VHE6
      Related
      ENSMUSP00000069751.7, ENSMUST00000067048.8
      Conserved Domains (6) summary
      pfam03028
      Location:39294610
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:248802
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:14021804
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:31993543
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:35723788
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:19392170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      28155000..28472191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520014.2XP_006520077.1  dynein axonemal heavy chain 5 isoform X1

      Conserved Domains (5) summary
      COG5245
      Location:16254267
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:235787
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:13841789
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:19242251
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:43114603
      Dynein_C; Dynein heavy chain C-terminal domain
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