Usp17le ubiquitin specific peptidase 17-like E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp17leprovided by MGI
Official Full Name: ubiquitin specific peptidase 17-like Eprovided by MGI
Primary source: MGI:MGI:107697
See related: Ensembl:ENSMUSG00000043073 AllianceGenome:MGI:107697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dub3; Dub6; DUB-3; USP17; Gm6596; USP17-E; Usp17l2; EG625530
Summary: Enables cysteine-type deubiquitinase activity. Acts upstream of or within protein deubiquitination. Predicted to be located in endoplasmic reticulum membrane and nucleolus. Predicted to be active in cytosol and nucleus. Orthologous to several human genes including USP17L1 (ubiquitin specific peptidase 17 like family member 1); USP17L10 (ubiquitin specific peptidase 17 like family member 10); and USP17L11 (ubiquitin specific peptidase 17 like family member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 E3; 7 55.69 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (104417168..104426677, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (104767961..104777470, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK4/CDK6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.
Title: CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.
Using a reporter assay, we show that NCoA1 potentiates Esrrb-mediated transcription of Dub3 and we present evidence of protein interaction between the SRC1 splice variant NCoA1 and Esrrb
Title: Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.
We show that Dub3 expression is strongly downregulated during neural conversion and precedes Cdc25A destabilization, while forced Dub3 expression in ESCs becomes lethal upon differentiation
Title: High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CAAX-box protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MDA-5 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of RIG-I signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G2/MI transition of meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 17-like protein E

Names: deubiquitinating enzyme 17-like protein 2; deubiquitinating enzyme 3; deubiquitinating enzyme 6; deubiquitinating protein 3; deubiquitinating protein 6; ubiquitin carboxyl-terminal hydrolase 17; ubiquitin carboxyl-terminal hydrolase 17-like protein 2; ubiquitin thioesterase 17-like protein 2; ubiquitin thiolesterase 17-like protein 2; ubiquitin-specific-processing protease 17-like protein 2

NP_001243902.1

EC 3.4.19.12

XP_011240180.1

EC 3.4.19.12

XP_017177923.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001256973.1 → NP_001243902.1 ubiquitin carboxyl-terminal hydrolase 17-like protein E

Status: VALIDATED

Source sequence(s)

AC110621

Consensus CDS

CCDS85368.1

UniProtKB/Swiss-Prot

D3YU85, Q7M764

UniProtKB/TrEMBL

A0A1B0GS33

Related

ENSMUSP00000147776.2, ENSMUST00000211384.2

Conserved Domains (2) summary

cd02661
Location:84 → 380

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:85 → 379

UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

104417168..104426677 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011241878.2 → XP_011240180.1 ubiquitin carboxyl-terminal hydrolase 17-like protein E isoform X2

UniProtKB/Swiss-Prot

D3YU85, Q7M764

Conserved Domains (1) summary

cd02661
Location:50 → 346

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
XM_017322434.1 → XP_017177923.1 ubiquitin carboxyl-terminal hydrolase 17-like protein E isoform X1

UniProtKB/Swiss-Prot

D3YU85, Q7M764

Conserved Domains (1) summary

cd02661
Location:84 → 380

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...