Myo3b myosin IIIB [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo3bprovided by MGI
Official Full Name: myosin IIIBprovided by MGI
Primary source: MGI:MGI:2448580
See related: Ensembl:ENSMUSG00000042064 AllianceGenome:MGI:2448580
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A430065P19Rik
Summary: Enables microfilament motor activity and protein serine/threonine kinase activity. Involved in inner ear morphogenesis; regulation of actin filament length; and sensory perception of sound. Acts upstream of or within positive regulation of filopodium assembly and protein phosphorylation. Located in filopodium tip; photoreceptor inner segment; and photoreceptor outer segment. Is active in stereocilium tip. Is expressed in several structures, including genitourinary system; nervous system; and submandibular gland. Orthologous to human MYO3B (myosin IIIB). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 8.0), kidney adult (RPKM 0.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 C2; 2 41.05 cM

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (69869464..70259542)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (70039126..70429195)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results uncover the critical role that class III myosins play redundantly in hair-bundle morphogenesis
Title: Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
When myosin IIIB (MYO3B) is coexpressed with espin-1 (ESPN1), MYO3B targets and carries ESPN1 to COS7 cell filopodia tips. This tip localization is lost when the ESPN1 C terminus actin-binding site is removed.
Title: Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

48.MMHAP4FLH6.seq (e-PCR)
- UniSTS:124689

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D2Mit489.1 (e-PCR), detects polymorphism
- UniSTS:129406

NoName (e-PCR)
- UniSTS:234421

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of filopodium assembly	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament length	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament length	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actin filament length	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
is_active_in filopodium tip	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium tip	IPI Inferred from Physical Interaction more info	PubMed
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in stereocilium tip	EXP Inferred from Experiment more info	PubMed
is_active_in stereocilium tip	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium tip	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin-IIIb

Names: myosin IIIB1; myosin IIIB2

NP_796350.2

EC 2.7.11.1

XP_006499808.1

EC 2.7.11.1

XP_006499813.1

EC 2.7.11.1

XP_017174526.1

EC 2.7.11.1

XP_017174527.1

EC 2.7.11.1

XP_017174528.1

EC 2.7.11.1

XP_017174529.1

EC 2.7.11.1

XP_017174530.1

EC 2.7.11.1

XP_017174531.1

EC 2.7.11.1

XP_017174532.1

EC 2.7.11.1

XP_017174534.1

EC 2.7.11.1

XP_030107661.1

EC 2.7.11.1

XP_036018214.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177376.5 → NP_796350.2 myosin-IIIb

See identical proteins and their annotated locations for NP_796350.2

Status: VALIDATED

Source sequence(s)

AL845263, AL929164, AL929249

Consensus CDS

CCDS38139.1

UniProtKB/TrEMBL

F8VQ79

Related

ENSMUSP00000055362.4, ENSMUST00000060208.11

Conserved Domains (4) summary

smart00220
Location:43 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00242
Location:362 → 1069

MYSc; Myosin. Large ATPases

cd06639
Location:20 → 310

STKc_myosinIIIB_N; N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin

cd01379
Location:373 → 1062

MYSc_Myo3; class III myosin, motor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

69869464..70259542

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319039.1 → XP_017174528.1 myosin-IIIb isoform X3

UniProtKB/Swiss-Prot

A2AR19, Q1EG26, Q1EG27

Related

ENSMUSP00000107862.2, ENSMUST00000112243.8

Conserved Domains (2) summary

cd01379
Location:345 → 1034

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_006499745.5 → XP_006499808.1 myosin-IIIb isoform X1

Conserved Domains (2) summary

cd01379
Location:345 → 1051

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_017319038.3 → XP_017174527.1 myosin-IIIb isoform X2

Conserved Domains (2) summary

cd01379
Location:345 → 1037

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_017319040.3 → XP_017174529.1 myosin-IIIb isoform X4

Conserved Domains (2) summary

cd01379
Location:323 → 1029

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 260

PKc_like; Protein Kinases, catalytic domain
XM_006499750.5 → XP_006499813.1 myosin-IIIb isoform X5

Conserved Domains (2) summary

cd01379
Location:310 → 1016

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 247

PKc_like; Protein Kinases, catalytic domain
XM_017319042.3 → XP_017174531.1 myosin-IIIb isoform X7

Conserved Domains (2) summary

cd01379
Location:345 → 1051

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_017319043.3 → XP_017174532.1 myosin-IIIb isoform X8

Conserved Domains (2) summary

cd01379
Location:345 → 1051

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_017319041.2 → XP_017174530.1 myosin-IIIb isoform X6

Conserved Domains (2) summary

cd01379
Location:345 → 1051

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_017319045.1 → XP_017174534.1 myosin-IIIb isoform X10

Conserved Domains (2) summary

cl22853
Location:345 → 862

Motor_domain; Myosin and Kinesin motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_030251801.1 → XP_030107661.1 myosin-IIIb isoform X11

Conserved Domains (1) summary

cl21453
Location:1 → 238

PKc_like; Protein Kinases, catalytic domain
XM_017319037.3 → XP_017174526.1 myosin-IIIb isoform X1

Conserved Domains (2) summary

cd01379
Location:345 → 1051

MYSc_Myo3; class III myosin, motor domain

cl21453
Location:1 → 282

PKc_like; Protein Kinases, catalytic domain
XM_036162321.1 → XP_036018214.1 myosin-IIIb isoform X9

Conserved Domains (4) summary

smart00015
Location:886 → 908

IQ; Calmodulin-binding motif

cd01379
Location:140 → 846

MYSc_Myo3; class III myosin, motor domain

cd22307
Location:878 → 926

Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

cl21453
Location:34 → 77

PKc_like; Protein Kinases, catalytic domain

RNA

XR_004940647.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001042509.1: Suppressed sequence

Description

NM_001042509.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.