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    Ogfr opioid growth factor receptor [ Mus musculus (house mouse) ]

    Gene ID: 72075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ogfrprovided by MGI
    Official Full Name
    opioid growth factor receptorprovided by MGI
    Primary source
    MGI:MGI:1919325
    See related
    Ensembl:ENSMUSG00000049401 AllianceGenome:MGI:1919325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010013E17Rik
    Summary
    Predicted to enable opioid growth factor receptor activity. Predicted to be located in cytoplasm; membrane; and nucleus. Is expressed in genitourinary system and metanephros. Orthologous to human OGFR (opioid growth factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 34.2), CNS E14 (RPKM 28.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ogfr in Genome Data Viewer
    Location:
    2 H4; 2 103.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180231200..180237630)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180589407..180595837)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene neurotensin receptor 1 Neighboring gene predicted gene, 30144 Neighboring gene STARR-positive B cell enhancer ABC_E9543 Neighboring gene STARR-positive B cell enhancer ABC_E4530 Neighboring gene MRG/MORF4L binding protein Neighboring gene collagen, type IX, alpha 3 Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene death inducer-obliterator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain. Kareem ZY, et al. Neuropeptides, 2023 Jun. PMID 36812665
    2. Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure. McLaughlin PJ, et al. Am J Physiol Regul Integr Comp Physiol, 2012 May. PMID 22338080
    3. Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse. Zagon IS, et al. Brain Res Mol Brain Res, 2000 Dec 8. PMID 11113537
    4. Temporal and spatial transcriptional programs in murine kidney development. Challen G, et al. Physiol Genomics, 2005 Oct 17. PMID 15998744
    5. The biology of the opioid growth factor receptor (OGFr). Zagon IS, et al. Brain Res Brain Res Rev, 2002 Feb. PMID 11890982

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain.
      Title: Opioid growth factor receptor: Anatomical distribution and receptor colocalization in neurons of the adult mouse brain.
    2. These data demonstrate for the first time that stable genetic amplification of OGFr downregulates homeostatic cell proliferation, as well as pathophysiological processes with respect to wound repair.
      Title: Targeted overexpression of OGFr in epithelium of transgenic mice suppresses cell proliferation and impairs full-thickness wound closure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables opioid growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    opioid growth factor receptor
    Names
    zeta-type opioid receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031373.3 → NP_113550.3  opioid growth factor receptor

      See identical proteins and their annotated locations for NP_113550.3

      Status: VALIDATED

      Source sequence(s)
      AF303894, CJ144579, CO040942
      Consensus CDS
      CCDS17179.1
      UniProtKB/Swiss-Prot
      A2ACT6, Q99L33, Q99PG2
      UniProtKB/TrEMBL
      Q80UU6
      Related
      ENSMUSP00000029087.4, ENSMUST00000029087.4
      Conserved Domains (3) summary
      PHA03169
      Location:284 → 548
      PHA03169; hypothetical protein; Provisional
      pfam04664
      Location:76 → 283
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region
      pfam15231
      Location:472 → 620
      VCX_VCY; Variable charge X/Y family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180231200..180237630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319269.3 → XP_017174758.1  opioid growth factor receptor isoform X1

      UniProtKB/TrEMBL
      Q80UU6
      Conserved Domains (3) summary
      PTZ00449
      Location:414 → 612
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03169
      Location:263 → 527
      PHA03169; hypothetical protein; Provisional
      pfam04664
      Location:55 → 262
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region

    2. XM_036162586.1 → XP_036018479.1  opioid growth factor receptor isoform X2

      UniProtKB/TrEMBL
      Q80UU6
      Conserved Domains (2) summary
      PTZ00449
      Location:349 → 547
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam04664
      Location:38 → 197
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PG2.1 GenPept UniProtKB/Swiss-Prot:Q99PG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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