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    Cd300c CD300C molecule [ Mus musculus (house mouse) ]

    Gene ID: 387565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd300cprovided by MGI
    Official Full Name
    CD300C moleculeprovided by MGI
    Primary source
    MGI:MGI:3032626
    See related
    Ensembl:ENSMUSG00000058728 AllianceGenome:MGI:3032626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clm6
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in regulation of innate immune response and signal transduction. Predicted to be active in plasma membrane. Orthologous to human CD300C (CD300c molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 2.6), mammary gland adult (RPKM 1.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd300c in Genome Data Viewer
    Location:
    11 E2; 11 80.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114846931..114851333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (114956105..114960507, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CD300A molecule Neighboring gene STARR-seq mESC enhancer starr_31138 Neighboring gene CD300 molecule like family member B Neighboring gene STARR-seq mESC enhancer starr_31139 Neighboring gene predicted gene 11699 Neighboring gene STARR-seq mESC enhancer starr_31140 Neighboring gene CD300 molecule like family member d Neighboring gene STARR-seq mESC enhancer starr_31141 Neighboring gene CD300C molecule 2 Neighboring gene CD300 molecule like family member D4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Kaitani A, et al. Sci Rep, 2018 May 29. PMID 29844322, Free PMC Article
    2. pDC-like cells are pre-DC2 and require KLF4 to control homeostatic CD4 T cells. Rodrigues PF, et al. Sci Immunol, 2023 Feb 24. PMID 36827419, Free PMC Article
    3. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. Chung DH, et al. J Immunol, 2003 Dec 15. PMID 14662855
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CLM-6 is an FcRgamma-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells
      Title: Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CMRF35-like molecule 6
    Names
    CD300 antigen-like family member C
    CD300C antigen
    CMRF-35-like molecule 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368239.1 → NP_001355168.1  CMRF35-like molecule 6 precursor

      Status: PROVISIONAL

      Source sequence(s)
      AL607025
      Consensus CDS
      CCDS88281.1
      UniProtKB/Swiss-Prot
      A2A7V7, Q6SJQ2
      UniProtKB/TrEMBL
      D3Z6G7
      Related
      ENSMUSP00000090123.7, ENSMUST00000092466.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      114846931..114851333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199225.1: Suppressed sequence

      Description
      NM_199225.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A7V7.1 GenPept UniProtKB/Swiss-Prot:A2A7V7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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