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    Pira6 paired-Ig-like receptor A6 [ Mus musculus (house mouse) ]

    Gene ID: 18729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pira6provided by MGI
    Official Full Name
    paired-Ig-like receptor A6provided by MGI
    Primary source
    MGI:MGI:1195974
    See related
    AllianceGenome:MGI:1195974
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    12M1; p91B; Pira10
    Summary
    Predicted to be involved in negative regulation of osteoclast differentiation. Orthologous to human LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
    Expression
    Biased expression in spleen adult (RPKM 7.2), mammary gland adult (RPKM 3.7) and 14 other tissues See more
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    Genomic context

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    See Pira6 in Genome Data Viewer
    Location:
    7; 7 A1

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic structure of mouse PIR-A6, an activating member of the paired immunoglobulin-like receptor gene family. Tun T, et al. Tissue Antigens, 2003 Mar. PMID 12694571
    2. Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family. Yamashita Y, et al. J Biochem, 1998 Feb. PMID 9538215
    3. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Kubagawa H, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144225, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    paired-Ig-like receptor A6
    Names
    killer cell inhibitory receptor-like protein p91B
    paired-Ig-like receptor A10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289428.1 → NP_001276357.1  paired-Ig-like receptor A6 isoform c precursor

      See identical proteins and their annotated locations for NP_001276357.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AY216658
      UniProtKB/TrEMBL
      O70434
      Conserved Domains (2) summary
      smart00410
      Location:529 → 617
      IG_like; Immunoglobulin like
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    2. NM_008848.1 → NP_032874.1  paired-Ig-like receptor A6 isoform a precursor

      See identical proteins and their annotated locations for NP_032874.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF041035
      UniProtKB/TrEMBL
      O55001, Q3ZB55
      Conserved Domains (2) summary
      smart00410
      Location:529 → 617
      IG_like; Immunoglobulin like
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    3. NM_011093.1 → NP_035223.1  paired-Ig-like receptor A6 isoform b precursor

      See identical proteins and their annotated locations for NP_035223.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (b) lacks two internal segments, compared to isoform a.
      Source sequence(s)
      U96687
      UniProtKB/TrEMBL
      A2NTK3, D3Z674
      Conserved Domains (2) summary
      smart00410
      Location:430 → 518
      IG_like; Immunoglobulin like
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_019130.1: Suppressed sequence

      Description
      NG_019130.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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