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    Bag6 BCL2-associated athanogene 6 [ Mus musculus (house mouse) ]

    Gene ID: 224727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bag6provided by MGI
    Official Full Name
    BCL2-associated athanogene 6provided by MGI
    Primary source
    MGI:MGI:1919439
    See related
    Ensembl:ENSMUSG00000024392 AllianceGenome:MGI:1919439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G3; Bat3; BAG-6; Scythe; D17H6S52E; 2410045D21Rik
    Summary
    Enables Hsp70 protein binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; protein stabilization; and synaptonemal complex assembly. Acts upstream of or within negative regulation of apoptotic process. Located in cytosol and nucleus. Is expressed in palatal shelf epithelium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 225.5), adrenal adult (RPKM 122.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bag6 in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35354132..35366297)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35135156..35147321)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 17, human D6S53E Neighboring gene apolipoprotein M Neighboring gene STARR-positive B cell enhancer ABC_E5599 Neighboring gene proline-rich coiled-coil 2A Neighboring gene STARR-positive B cell enhancer ABC_E3201 Neighboring gene STARR-positive B cell enhancer ABC_E2486 Neighboring gene predicted gene, 23442 Neighboring gene STARR-positive B cell enhancer ABC_E5600 Neighboring gene allograft inflammatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly. Zhou Y, et al. PLoS Pathog, 2024 Mar. PMID 38498560, Free PMC Article
    2. The human BAT3 ortholog in rodents is predominantly and developmentally expressed in testis. Wang R, et al. Mol Cell Biochem, 1994 Jul 13. PMID 7854331
    3. BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals. Song H, et al. Cell Prolif, 2022 Jul. PMID 35688694, Free PMC Article
    4. Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function. Tang R, et al. Sci Immunol, 2022 Mar 11. PMID 35275752, Free PMC Article
    5. HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling. Goto K, et al. Cell Death Dis, 2011 Dec 1. PMID 22130070, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells.
      Title: BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells.
    2. Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
      Title: Differential lung gene expression identified Zscan2 and Bag6 as novel tissue repair players in an experimental COPD model.
    3. BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
      Title: BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
    4. BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
      Title: BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
    5. BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.
      Title: BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.
    6. Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model.
      Title: Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model.
    7. Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.
      Title: Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.
    8. BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
      Title: BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
    9. The cleft palate candidate gene BAG6 supports FoxO1 acetylation topromote FasL-mediated apoptosis during palate fusion.
      Title: The cleft palate candidate gene BAG6 supports FoxO1 acetylation to promote FasL-mediated apoptosis during palate fusion.
    10. BAT3 negatively regulates lipopolysaccharide-induced NF-kappaB signaling through TRAF6.
      Title: BAT3 negatively regulates lipopolysaccharide-induced NF-κB signaling through TRAF6.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables misfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables misfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-specific protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in NK T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum stress-induced pre-emptive quality control ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum stress-induced pre-emptive quality control ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response-activating cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-activating cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in internal peptidyl-lysine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lung development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of unfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in natural killer cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in natural killer cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of BAT3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BAT3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of BAT3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    large proline-rich protein BAG6
    Names
    BAG family molecular chaperone regulator 6
    HLA-B-associated transcript 3
    large proline-rich protein BAT3
    protein Scythe

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252468.2 → NP_001239397.1  large proline-rich protein BAG6 isoform 2

      See identical proteins and their annotated locations for NP_001239397.1

      Status: VALIDATED

      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS57073.1
      UniProtKB/TrEMBL
      G3UYQ2, Q3UF95
      Related
      ENSMUSP00000129324.3, ENSMUST00000166426.9
      Conserved Domains (3) summary
      PRK07764
      Location:909 → 1100
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    2. NM_001252469.2 → NP_001239398.1  large proline-rich protein BAG6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS57072.1
      UniProtKB/TrEMBL
      G3UYQ2, G3UZT6
      Related
      ENSMUSP00000134628.2, ENSMUST00000173550.8
      Conserved Domains (3) summary
      PRK07764
      Location:944 → 1122
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    3. NM_001372260.1 → NP_001359189.1  large proline-rich protein BAG6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:963 → 1154
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    4. NM_001372261.1 → NP_001359190.1  large proline-rich protein BAG6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:962 → 1153
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    5. NM_001372262.1 → NP_001359191.1  large proline-rich protein BAG6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:945 → 1136
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    6. NM_001372265.1 → NP_001359194.1  large proline-rich protein BAG6 isoform 7

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1147
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    7. NM_001372266.1 → NP_001359195.1  large proline-rich protein BAG6 isoform 12

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1105
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    8. NM_001372267.1 → NP_001359196.1  large proline-rich protein BAG6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/Swiss-Prot
      Q8SNA3, Q9Z1R2
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1118
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    9. NM_001372268.1 → NP_001359197.1  large proline-rich protein BAG6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28688.1
      UniProtKB/Swiss-Prot
      Q8SNA3, Q9Z1R2
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1118
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    10. NM_001372269.1 → NP_001359198.1  large proline-rich protein BAG6 isoform 18

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1117
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    11. NM_001372270.1 → NP_001359199.1  large proline-rich protein BAG6 isoform 18

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1117
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    12. NM_001372271.1 → NP_001359200.1  large proline-rich protein BAG6 isoform 18

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1117
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    13. NM_001372272.1 → NP_001359201.1  large proline-rich protein BAG6 isoform 18

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1117
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    14. NM_001372273.1 → NP_001359202.1  large proline-rich protein BAG6 isoform 8

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1146
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    15. NM_001372274.1 → NP_001359203.1  large proline-rich protein BAG6 isoform 8

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1146
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    16. NM_001372275.1 → NP_001359204.1  large proline-rich protein BAG6 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:963 → 1141
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    17. NM_001372276.1 → NP_001359205.1  large proline-rich protein BAG6 isoform 10

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:962 → 1140
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    18. NM_001372277.1 → NP_001359206.1  large proline-rich protein BAG6 isoform 10

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Related
      ENSMUSP00000134425.2, ENSMUST00000174281.9
      Conserved Domains (3) summary
      PRK07764
      Location:962 → 1140
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    19. NM_001372278.1 → NP_001359207.1  large proline-rich protein BAG6 isoform 10

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:962 → 1140
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    20. NM_001372279.1 → NP_001359208.1  large proline-rich protein BAG6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2, Q3UF95
      Conserved Domains (3) summary
      PRK07764
      Location:909 → 1100
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    21. NM_001372280.1 → NP_001359209.1  large proline-rich protein BAG6 isoform 11

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:908 → 1099
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    22. NM_001372281.1 → NP_001359210.1  large proline-rich protein BAG6 isoform 11

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:908 → 1099
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    23. NM_001372282.1 → NP_001359211.1  large proline-rich protein BAG6 isoform 11

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:908 → 1099
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    24. NM_001372283.1 → NP_001359212.1  large proline-rich protein BAG6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2, G3UZT6
      Conserved Domains (3) summary
      PRK07764
      Location:944 → 1122
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    25. NM_001372284.1 → NP_001359213.1  large proline-rich protein BAG6 isoform 12

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1105
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    26. NM_001372285.1 → NP_001359214.1  large proline-rich protein BAG6 isoform 12

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1105
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    27. NM_001372286.1 → NP_001359215.1  large proline-rich protein BAG6 isoform 13

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1104
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    28. NM_001372287.1 → NP_001359216.1  large proline-rich protein BAG6 isoform 13

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1104
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    29. NM_001372288.1 → NP_001359217.1  large proline-rich protein BAG6 isoform 14

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:926 → 1064
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    30. NM_001372289.1 → NP_001359218.1  large proline-rich protein BAG6 isoform 15

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:908 → 1086
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    31. NM_001372290.1 → NP_001359219.1  large proline-rich protein BAG6 isoform 15

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Related
      ENSMUSP00000134175.2, ENSMUST00000172571.8
      Conserved Domains (3) summary
      PRK07764
      Location:908 → 1086
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    32. NM_001372291.1 → NP_001359220.1  large proline-rich protein BAG6 isoform 16

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:901 → 1079
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    33. NM_001404327.1 → NP_001391256.1  large proline-rich protein BAG6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

    34. NM_001404328.1 → NP_001391257.1  large proline-rich protein BAG6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

    35. NM_001404329.1 → NP_001391258.1  large proline-rich protein BAG6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

    36. NM_001404330.1 → NP_001391259.1  large proline-rich protein BAG6 isoform 17

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      G3UYQ2

    37. NM_001404331.1 → NP_001391260.1  large proline-rich protein BAG6 isoform 9

      Status: VALIDATED

      Source sequence(s)
      CR974444
      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4

    38. NM_057171.3 → NP_476512.1  large proline-rich protein BAG6 isoform 1

      See identical proteins and their annotated locations for NP_476512.1

      Status: VALIDATED

      Source sequence(s)
      CR974444
      Consensus CDS
      CCDS28688.1
      UniProtKB/Swiss-Prot
      Q8SNA3, Q9Z1R2
      UniProtKB/TrEMBL
      G3UYQ2
      Related
      ENSMUSP00000025250.8, ENSMUST00000025250.14
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1118
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35354132..35366297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524117.4 → XP_006524180.1  large proline-rich protein BAG6 isoform X9

      See identical proteins and their annotated locations for XP_006524180.1

      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:945 → 1136
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    2. XM_030249713.1 → XP_030105573.1  large proline-rich protein BAG6 isoform X10

      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:944 → 1135
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)

    3. XM_006524118.4 → XP_006524181.1  large proline-rich protein BAG6 isoform X14

      See identical proteins and their annotated locations for XP_006524181.1

      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:1004 → 1195
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    4. XM_006524115.3 → XP_006524178.1  large proline-rich protein BAG6 isoform X7

      See identical proteins and their annotated locations for XP_006524178.1

      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:1004 → 1182
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    5. XM_017317432.2 → XP_017172921.1  large proline-rich protein BAG6 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:1004 → 1224
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    6. XM_017317434.2 → XP_017172923.1  large proline-rich protein BAG6 isoform X8

      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:1004 → 1142
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    7. XM_036160539.1 → XP_036016432.1  large proline-rich protein BAG6 isoform X2

      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:1003 → 1223
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    8. XM_036160541.1 → XP_036016434.1  large proline-rich protein BAG6 isoform X6

      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:968 → 1188
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    9. XM_030249721.1 → XP_030105581.1  large proline-rich protein BAG6 isoform X13

      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:968 → 1106
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:319 → 433
      DUF3538; Domain of unknown function (DUF3538)

    10. XM_030249712.2 → XP_030105572.1  large proline-rich protein BAG6 isoform X3

      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:985 → 1176
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:58 → 128
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:301 → 415
      DUF3538; Domain of unknown function (DUF3538)

    11. XM_030249715.2 → XP_030105575.1  large proline-rich protein BAG6 isoform X11

      UniProtKB/Swiss-Prot
      Q8SNA3, Q9Z1R2
      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:927 → 1118
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    12. XM_006524113.4 → XP_006524176.1  large proline-rich protein BAG6 isoform X4

      See identical proteins and their annotated locations for XP_006524176.1

      UniProtKB/TrEMBL
      A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
      Conserved Domains (3) summary
      PRK07764
      Location:963 → 1154
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:278 → 392
      DUF3538; Domain of unknown function (DUF3538)

    13. XM_030249711.1 → XP_030105571.1  large proline-rich protein BAG6 isoform X9

      UniProtKB/TrEMBL
      G3UYQ2
      Conserved Domains (3) summary
      PRK07764
      Location:945 → 1136
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd01809
      Location:17 → 87
      Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
      pfam12057
      Location:260 → 374
      DUF3538; Domain of unknown function (DUF3538)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1R2.1 GenPept UniProtKB/Swiss-Prot:Q9Z1R2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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