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    Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [ Mus musculus (house mouse) ]

    Gene ID: 21951, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnksprovided by MGI
    Official Full Name
    tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymeraseprovided by MGI
    Primary source
    MGI:MGI:1341087
    See related
    Ensembl:ENSMUSG00000031529 AllianceGenome:MGI:1341087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARTD5; TANK1; Parp5a; mTNKS1; 4930554K12Rik; D130072O21Rik
    Summary
    Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity; histone binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and oocyte. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.3), whole brain E14.5 (RPKM 14.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tnks in Genome Data Viewer
    Location:
    8 A4; 8 21.16 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (35296333..35432844, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (34829179..34965690, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46069 Neighboring gene STARR-seq mESC enhancer starr_21171 Neighboring gene STARR-positive B cell enhancer ABC_E8233 Neighboring gene STARR-positive B cell enhancer ABC_E6632 Neighboring gene STARR-positive B cell enhancer ABC_E6633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:35867988-35868175 Neighboring gene STARR-positive B cell enhancer ABC_E1363 Neighboring gene dual specificity phosphatase 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:36008219-36008402 Neighboring gene STARR-positive B cell enhancer ABC_E558 Neighboring gene STARR-seq mESC enhancer starr_21179 Neighboring gene predicted gene, 34368 Neighboring gene STARR-seq mESC enhancer starr_21180 Neighboring gene predicted gene, 34419 Neighboring gene chromodomain helicase DNA binding protein 6 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in cell division  
    involved_in cellular response to nutrient  
    involved_in mRNA transport  
    involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric  
    involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric  
    involved_in negative regulation of telomere maintenance via telomere lengthening  
    involved_in negative regulation of telomere maintenance via telomere lengthening  
    involved_in negative regulation of telomeric DNA binding  
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of telomere capping  
    involved_in positive regulation of telomere capping  
    involved_in positive regulation of telomere capping  
    involved_in positive regulation of telomere maintenance via telomerase  
    involved_in positive regulation of telomere maintenance via telomerase  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein auto-ADP-ribosylation  
    involved_in protein auto-ADP-ribosylation  
    involved_in protein localization to chromosome, telomeric region  
    involved_in protein localization to chromosome, telomeric region  
    involved_in protein localization to chromosome, telomeric region  
    involved_in protein poly-ADP-ribosylation  
    involved_in protein poly-ADP-ribosylation  
    involved_in protein polyubiquitination  
    involved_in protein polyubiquitination  
    involved_in protein transport  
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in centrosome  
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    located_in mitotic spindle pole  
    located_in mitotic spindle pole  
    located_in nuclear body  
    located_in nuclear body  
    located_in nuclear membrane  
    located_in nuclear membrane  
    part_of nuclear pore  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase tankyrase-1
    Names
    ADP-ribosyltransferase diphtheria toxin-like 5
    TRF1-interacting ankyrin-related ADP-ribose polymerase 1
    protein poly-ADP-ribosyltransferase tankyrase-1
    tankyrase I
    tankyrase-1
    NP_780300.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175091.3NP_780300.2  poly [ADP-ribose] polymerase tankyrase-1

      See identical proteins and their annotated locations for NP_780300.2

      Status: VALIDATED

      Source sequence(s)
      AC122458, AK080913, BC057370
      Consensus CDS
      CCDS22242.1
      UniProtKB/Swiss-Prot
      Q6PFX9, Q8BX62
      Related
      ENSMUSP00000033929.5, ENSMUST00000033929.6
      Conserved Domains (8) summary
      cd09524
      Location:10171082
      SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
      smart00454
      Location:10231080
      SAM; Sterile alpha motif
      cd00204
      Location:669794
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01438
      Location:10841306
      tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
      pfam00644
      Location:10981301
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      pfam12796
      Location:681773
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:796850
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:364392
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      35296333..35432844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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