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    Atp10b ATPase, class V, type 10B [ Mus musculus (house mouse) ]

    Gene ID: 319767, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atp10bprovided by MGI
    Official Full Name
    ATPase, class V, type 10Bprovided by MGI
    Primary source
    MGI:MGI:2442688
    See related
    Ensembl:ENSMUSG00000055415 AllianceGenome:MGI:2442688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5930426O13Rik; 9030605H24Rik
    Summary
    Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in lysosomal membrane organization and phospholipid translocation. Predicted to be located in endoplasmic reticulum; late endosome membrane; and lysosomal membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Orthologous to human ATP10B (ATPase phospholipid transporting 10B (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 11.0), large intestine adult (RPKM 9.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp10b in Genome Data Viewer
    Location:
    11 A5; 11 25.68 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (42902991..43153112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43012164..43262285)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34591 Neighboring gene gamma-aminobutyric acid type A receptor subunit beta 2 Neighboring gene STARR-seq mESC enhancer starr_29249 Neighboring gene STARR-seq mESC enhancer starr_29250 Neighboring gene STARR-seq mESC enhancer starr_29251 Neighboring gene predicted gene, 34644 Neighboring gene STARR-seq mESC enhancer starr_29252 Neighboring gene STARR-seq mESC enhancer starr_29253 Neighboring gene STARR-positive B cell enhancer mm9_chr11:42987971-42988272 Neighboring gene predicted gene 12146 Neighboring gene predicted gene, 51418 Neighboring gene STARR-positive B cell enhancer ABC_E11475 Neighboring gene STARR-positive B cell enhancer mm9_chr11:43172342-43172643 Neighboring gene STARR-positive B cell enhancer ABC_E9138 Neighboring gene microRNA 146 Neighboring gene predicted gene 5782

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosylceramide flippase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosylceramide flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosomal membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosomal membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase VB
    Names
    potential phospholipid-transporting ATPase VB
    probable phospholipid-transporting ATPase VB
    NP_795973.2
    XP_006533597.1
    XP_017170095.1
    XP_036012652.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428744.1 → NP_001415673.1  phospholipid-transporting ATPase VB

      Status: VALIDATED

      Source sequence(s)
      AL672181, AL772227, AL935157
      UniProtKB/Swiss-Prot
      B1AWN4

    2. NM_176999.4 → NP_795973.2  phospholipid-transporting ATPase VB

      See identical proteins and their annotated locations for NP_795973.2

      Status: VALIDATED

      Source sequence(s)
      AL772227, AL935157
      Consensus CDS
      CCDS36129.1
      UniProtKB/Swiss-Prot
      B1AWN4
      Related
      ENSMUSP00000076844.6, ENSMUST00000077659.6
      Conserved Domains (1) summary
      cd02073
      Location:68 → 1211
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      42902991..43153112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314606.2 → XP_017170095.1  phospholipid-transporting ATPase VB isoform X1

      Conserved Domains (1) summary
      cd02073
      Location:68 → 1211
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

    2. XM_036156759.1 → XP_036012652.1  phospholipid-transporting ATPase VB isoform X3

      Conserved Domains (1) summary
      cl21460
      Location:1 → 1105
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    3. XM_006533534.4 → XP_006533597.1  phospholipid-transporting ATPase VB isoform X2

      UniProtKB/TrEMBL
      A0A571BEJ2
      Related
      ENSMUSP00000158770.2, ENSMUST00000238415.2
      Conserved Domains (1) summary
      cd02073
      Location:40 → 1183
      P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AWN4.1 GenPept UniProtKB/Swiss-Prot:B1AWN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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