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    Usp21 ubiquitin specific peptidase 21 [ Mus musculus (house mouse) ]

    Gene ID: 30941, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp21provided by MGI
    Official Full Name
    ubiquitin specific peptidase 21provided by MGI
    Primary source
    MGI:MGI:1353665
    See related
    Ensembl:ENSMUSG00000053483 AllianceGenome:MGI:1353665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Usp16; Usp23; ESTM28
    Summary
    Enables cysteine-type deubiquitinase activity and transcription coactivator activity. Involved in transcription initiation-coupled chromatin remodeling. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in left lung; primary oocyte; right lung; and submandibular gland primordium. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 28.1), CNS E14 (RPKM 27.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Usp21 in Genome Data Viewer
    Location:
    1 H3; 1 79.3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171109523..171115534, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171281949..171287961, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 Neighboring gene protoporphyrinogen oxidase Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene STARR-seq mESC enhancer starr_03027 Neighboring gene ribosomal protein L27, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity PubMed 
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type deubiquitinase activity  
    enables cysteine-type peptidase activity PubMed 
    enables cysteine-type peptidase activity  
    enables cysteine-type peptidase activity  
    enables deNEDDylase activity  
    enables deNEDDylase activity  
    enables metal ion binding  
    enables transcription coactivator activity PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 21
    Names
    deubiquitinating enzyme 21
    ubiquitin specific protease 21
    ubiquitin specific protease 23
    ubiquitin thioesterase 21
    ubiquitin thiolesterase 21
    ubiquitin-specific-processing protease 21
    NP_038947.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013919.4NP_038947.2  ubiquitin carboxyl-terminal hydrolase 21

      Status: VALIDATED

      Source sequence(s)
      AF177759, AK011148, BP770216, BY110597
      Consensus CDS
      CCDS35774.1
      UniProtKB/Swiss-Prot
      Q9D0R1, Q9QZL6
      UniProtKB/TrEMBL
      E9PUE2
      Related
      ENSMUSP00000064002.6, ENSMUST00000065941.12
      Conserved Domains (1) summary
      pfam00443
      Location:212556
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171109523..171115534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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