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    Map2k3 mitogen-activated protein kinase kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 26397, updated on 9-Dec-2024

    Summary

    Official Symbol
    Map2k3provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase 3provided by MGI
    Primary source
    MGI:MGI:1346868
    See related
    Ensembl:ENSMUSG00000018932 AllianceGenome:MGI:1346868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MEK3; MKK3; MKK3b; Prkmk3; MAPKK 3
    Summary
    Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 35.9), small intestine adult (RPKM 30.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Map2k3 in Genome Data Viewer
    Location:
    11 B2; 11 37.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60822880..60843637)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60932054..60952811)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_29662 Neighboring gene predicted gene, 39830 Neighboring gene mitogen-activated protein kinase kinase 3, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E2993 Neighboring gene predicted gene, 35681 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables JUN kinase kinase activity  
    enables MAP kinase kinase activity  
    enables MAP kinase kinase activity PubMed 
    enables MAP kinase kinase activity PubMed 
    enables MAP kinase kinase activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 29
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in MAPK cascade  
    acts_upstream_of_or_within MAPK cascade PubMed 
    acts_upstream_of_or_within MAPK cascade PubMed 
    acts_upstream_of_or_within cardiac muscle contraction PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to sorbitol  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in chromatin remodeling  
    involved_in heart development  
    acts_upstream_of_or_within inflammatory response PubMed 
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of hippo signaling  
    involved_in p38MAPK cascade  
    involved_in p38MAPK cascade  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein phosphorylation  
    acts_upstream_of_or_within regulation of cytokine production PubMed 
    involved_in response to ischemia  
    involved_in stress-activated protein kinase signaling cascade  
    involved_in stress-activated protein kinase signaling cascade  
    Items 1 - 25 of 29

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 3
    Names
    MAP kinase kinase 3
    MAPK/ERK kinase 3
    NP_032954.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008928.5NP_032954.1  dual specificity mitogen-activated protein kinase kinase 3

      See identical proteins and their annotated locations for NP_032954.1

      Status: VALIDATED

      Source sequence(s)
      AL603830
      Consensus CDS
      CCDS24804.1
      UniProtKB/Swiss-Prot
      O09110, P97293, Q91VX1
      UniProtKB/TrEMBL
      Q3TLX7, Q3TX82, Q3UDI2, Q5SWN9
      Related
      ENSMUSP00000019076.4, ENSMUST00000019076.10
      Conserved Domains (1) summary
      cd06617
      Location:62344
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    RNA

    1. NR_157293.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL603830
      Related
      ENSMUST00000130269.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60822880..60843637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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