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    Lama3 laminin, alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 16774, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lama3provided by MGI
    Official Full Name
    laminin, alpha 3provided by MGI
    Primary source
    MGI:MGI:99909
    See related
    Ensembl:ENSMUSG00000024421 AllianceGenome:MGI:99909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [a]3B; Lama3B
    Summary
    Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including axon guidance; cell-cell adhesion; and hemidesmosome assembly. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Used to study junctional epidermolysis bullosa and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to human LAMA3 (laminin subunit alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 9.8), colon adult (RPKM 3.3) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lama3 in Genome Data Viewer
    Location:
    18 A1; 18 6.2 cM
    Exon count:
    78
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12466806..12716070)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12333417..12583013)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene regulator of MON1-CCZ1 Neighboring gene STARR-positive B cell enhancer ABC_E2504 Neighboring gene STARR-seq mESC enhancer starr_43833 Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene ecotropic viral integration site 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43835 Neighboring gene STARR-positive B cell enhancer ABC_E8704 Neighboring gene predicted gene, 36232 Neighboring gene STARR-seq mESC enhancer starr_43837 Neighboring gene predicted gene 29200 Neighboring gene STARR-seq mESC enhancer starr_43839 Neighboring gene STARR-seq mESC enhancer starr_43841 Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene STARR-seq mESC enhancer starr_43842 Neighboring gene predicted gene, 41668 Neighboring gene microRNA 1948

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent  
    enables extracellular matrix structural constituent PubMed 
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis  
    involved_in axon guidance  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion  
    involved_in endodermal cell differentiation  
    involved_in hemidesmosome assembly  
    involved_in hemidesmosome assembly  
    involved_in regulation of cell adhesion  
    involved_in regulation of cell migration  
    involved_in regulation of embryonic development  
    involved_in tissue development  
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in adherens junction  
    is_active_in basement membrane  
    located_in basement membrane PubMed 
    located_in collagen-containing extracellular matrix PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in extracellular region  
    located_in hemidesmosome  
    located_in hemidesmosome  
    part_of laminin-3 complex  
    part_of laminin-3 complex  
    part_of laminin-5 complex PubMed 

    General protein information

    Preferred Names
    laminin subunit alpha-3
    Names
    epiligrin subunit alpha
    kalinin subunit alpha
    laminin-5 subunit alpha
    laminin-6 subunit alpha
    laminin-7 subunit alpha
    nicein subunit alpha
    nicein, 150kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347461.2NP_001334390.1  laminin subunit alpha-3 isoform 3A precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (3A) with a distinct N-terminus, compared to isoform 3B.
      Source sequence(s)
      AC102131, AC139027
      Consensus CDS
      CCDS84360.1
      UniProtKB/Swiss-Prot
      Q61789
      Related
      ENSMUSP00000140104.2, ENSMUST00000188815.2
    2. NM_010680.2NP_034810.1  laminin subunit alpha-3 isoform 3B precursor

      See identical proteins and their annotated locations for NP_034810.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (3B).
      Source sequence(s)
      AC102131, AC102248, AC139027, AC157909
      Consensus CDS
      CCDS50222.1
      UniProtKB/Swiss-Prot
      E9PUR4, O08751, Q61788, Q61789, Q61966, Q9JHQ7
      Related
      ENSMUSP00000089703.7, ENSMUST00000092070.13
      Conserved Domains (10) summary
      smart00136
      Location:40294
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:15091638
      LamB; Laminin B domain
      smart00282
      Location:24312566
      LamG; Laminin G domain
      cd00055
      Location:14011451
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:31553306
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:12631311
      Laminin_EGF; Laminin EGF domain
      pfam06008
      Location:18422101
      Laminin_I; Laminin Domain I
      pfam06009
      Location:22842412
      Laminin_II; Laminin Domain II
      pfam17045
      Location:19682248
      CEP63; Centrosomal protein of 63 kDa
      cl21509
      Location:20902204
      ApoLp-III_like; Apolipophorin-III and similar insect proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      12466806..12716070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525691.5XP_006525754.1  laminin subunit alpha-3 isoform X6

      Conserved Domains (4) summary
      smart00136
      Location:40294
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:15091638
      LamB; Laminin B domain
      cd00055
      Location:14011451
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:12631311
      Laminin_EGF; Laminin EGF domain
    2. XM_036160997.1XP_036016890.1  laminin subunit alpha-3 isoform X2

      Conserved Domains (9) summary
      smart00136
      Location:40294
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:15091638
      LamB; Laminin B domain
      smart00282
      Location:24322567
      LamG; Laminin G domain
      PRK11281
      Location:20622380
      PRK11281; mechanosensitive channel MscK
      cd00055
      Location:14011451
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:25992739
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:18442101
      Laminin_I; Laminin Domain I
      pfam06009
      Location:22852413
      Laminin_II; Laminin Domain II
      pfam00053
      Location:12631311
      Laminin_EGF; Laminin EGF domain
    3. XM_006525685.5XP_006525748.1  laminin subunit alpha-3 isoform X1

      Conserved Domains (9) summary
      smart00136
      Location:40294
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:15091638
      LamB; Laminin B domain
      smart00282
      Location:24322567
      LamG; Laminin G domain
      cd00055
      Location:14011451
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:31563307
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:20622329
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:18442101
      Laminin_I; Laminin Domain I
      pfam00053
      Location:12631311
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:22852413
      Laminin_II; Laminin Domain II
    4. XM_006525687.5XP_006525750.1  laminin subunit alpha-3 isoform X3

      Conserved Domains (8) summary
      smart00281
      Location:348477
      LamB; Laminin B domain
      smart00282
      Location:12711406
      LamG; Laminin G domain
      cd00055
      Location:240290
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:19952146
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:9011168
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam06008
      Location:683940
      Laminin_I; Laminin Domain I
      pfam00053
      Location:102150
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:11241252
      Laminin_II; Laminin Domain II
    5. XM_036160998.1XP_036016891.1  laminin subunit alpha-3 isoform X4

      Conserved Domains (9) summary
      smart00281
      Location:35164
      LamB; Laminin B domain
      smart00282
      Location:9581093
      LamG; Laminin G domain
      PRK11281
      Location:588906
      PRK11281; mechanosensitive channel MscK
      cd00055
      Location:209255
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:16821833
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00185
      Location:292330
      TNFRSF; CRD2 [structural motif]
      pfam06008
      Location:370627
      Laminin_I; Laminin Domain I
      pfam06009
      Location:811939
      Laminin_II; Laminin Domain II
      cl22855
      Location:277345
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    6. XM_006525689.3XP_006525752.1  laminin subunit alpha-3 isoform X5

      Conserved Domains (7) summary
      smart00282
      Location:826961
      LamG; Laminin G domain
      cd00055
      Location:77123
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:15501701
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      TIGR02168
      Location:456723
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd00185
      Location:148217
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
      pfam06008
      Location:238495
      Laminin_I; Laminin Domain I
      pfam06009
      Location:679807
      Laminin_II; Laminin Domain II

    RNA

    1. XR_385977.5 RNA Sequence

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