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    Tgfb3 transforming growth factor, beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 21809, updated on 24-Dec-2024

    Summary

    Official Symbol
    Tgfb3provided by MGI
    Official Full Name
    transforming growth factor, beta 3provided by MGI
    Primary source
    MGI:MGI:98727
    See related
    Ensembl:ENSMUSG00000021253 AllianceGenome:MGI:98727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tgfb-3; TGF-beta-3
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Homozygous knockout mice for this gene exhibit cleft palate, delayed pulmonary development and neonatal death. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in limb E14.5 (RPKM 30.0), ovary adult (RPKM 18.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Tgfb3 in Genome Data Viewer
    Location:
    12 D2; 12 40.09 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86103517..86125815, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86056743..86079041, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tubulin tyrosine ligase-like family, member 5 Neighboring gene predicted gene, 51990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:87310644-87310901 Neighboring gene STARR-positive B cell enhancer ABC_E5341 Neighboring gene predicted gene, 51989 Neighboring gene predicted gene, 37804 Neighboring gene intraflagellar transport 43 Neighboring gene STARR-seq mESC enhancer starr_32794 Neighboring gene predicted gene 805 Neighboring gene predicted gene, 32473

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC118722

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity  
    enables growth factor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein-containing complex binding  
    enables transforming growth factor beta binding  
    enables transforming growth factor beta binding  
    enables type I transforming growth factor beta receptor binding  
    enables type I transforming growth factor beta receptor binding  
    enables type II transforming growth factor beta receptor binding  
    enables type II transforming growth factor beta receptor binding  
    enables type III transforming growth factor beta receptor binding  
    enables type III transforming growth factor beta receptor binding  
    Items 1 - 25 of 62
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of cell population proliferation PubMed 
    involved_in cell-cell junction organization  
    involved_in cell-cell junction organization  
    acts_upstream_of_or_within cellular response to growth factor stimulus PubMed 
    involved_in detection of hypoxia  
    involved_in detection of hypoxia  
    acts_upstream_of_or_within embryo development PubMed 
    involved_in embryonic neurocranium morphogenesis  
    acts_upstream_of epithelial cell proliferation PubMed 
    involved_in face morphogenesis PubMed 
    involved_in face morphogenesis  
    involved_in face morphogenesis  
    acts_upstream_of filopodium assembly PubMed 
    acts_upstream_of_or_within_positive_effect gene expression PubMed 
    acts_upstream_of_or_within in utero embryonic development PubMed 
    involved_in lung alveolus development PubMed 
    acts_upstream_of_or_within mammary gland development PubMed 
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
    involved_in negative regulation of macrophage cytokine production  
    involved_in negative regulation of macrophage cytokine production  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    acts_upstream_of neuron apoptotic process PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cell division  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of collagen biosynthetic process  
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition  
    acts_upstream_of_or_within positive regulation of filopodium assembly PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of tight junction disassembly  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of cell population proliferation  
    NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation PubMed 
    involved_in response to estrogen  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in response to progesterone  
    involved_in response to progesterone  
    acts_upstream_of_or_within roof of mouth development PubMed 
    involved_in salivary gland morphogenesis  
    involved_in secondary palate development PubMed 
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    Items 1 - 25 of 62
    Component Evidence Code Pubs
    located_in T-tubule  
    located_in cell surface  
    located_in collagen-containing extracellular matrix  
    located_in extracellular matrix PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    located_in neuronal cell body  
    located_in secretory granule  

    General protein information

    Preferred Names
    transforming growth factor beta-3 proprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009368.3NP_033394.2  transforming growth factor beta-3 proprotein precursor

      See identical proteins and their annotated locations for NP_033394.2

      Status: REVIEWED

      Source sequence(s)
      AC134328, AK162560, AW122646, BC089347
      Consensus CDS
      CCDS49116.1
      UniProtKB/TrEMBL
      Q3UFN7, Q91YU7
      Related
      ENSMUSP00000003687.7, ENSMUST00000003687.8
      Conserved Domains (2) summary
      pfam00688
      Location:24230
      TGFb_propeptide; TGF-beta propeptide
      cd19386
      Location:312412
      TGF_beta_TGFB3; transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      86103517..86125815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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