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    Defb4 defensin beta 4 [ Mus musculus (house mouse) ]

    Gene ID: 56519, updated on 27-Nov-2024

    Summary

    Official Symbol
    Defb4provided by MGI
    Official Full Name
    defensin beta 4provided by MGI
    Primary source
    MGI:MGI:1927667
    See related
    Ensembl:ENSMUSG00000059230 AllianceGenome:MGI:1927667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BD-4; 2310001F05Rik
    Summary
    Enables CCR6 chemokine receptor binding activity. Involved in chemotaxis; defense response to Gram-negative bacterium; and defense response to Gram-positive bacterium. Acts upstream of or within defense response to bacterium. Predicted to be active in extracellular space. Orthologous to human DEFB4A (defensin beta 4A) and DEFB4B (defensin beta 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward lung adult (RPKM 3.8) See more
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    Genomic context

    See Defb4 in Genome Data Viewer
    Location:
    8 A1.3; 8 10.35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19248720..19251563)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19198704..19201547)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53432 Neighboring gene defensin beta 14 Neighboring gene predicted gene, 39139 Neighboring gene STARR-seq mESC enhancer starr_20861 Neighboring gene defensin, alpha, pseudogene 12 Neighboring gene defensin beta 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CCR6 chemokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables CCR6 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019728.4NP_062702.1  beta-defensin 4 precursor

      See identical proteins and their annotated locations for NP_062702.1

      Status: VALIDATED

      Source sequence(s)
      AK009061, AV083507, EH111306
      Consensus CDS
      CCDS40254.1
      UniProtKB/Swiss-Prot
      P82019
      UniProtKB/TrEMBL
      Q499H9
      Related
      ENSMUSP00000079808.3, ENSMUST00000081017.3
      Conserved Domains (1) summary
      pfam00711
      Location:2861
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      19248720..19251563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)