U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Trappc2 trafficking protein particle complex 2 [ Mus musculus (house mouse) ]

    Gene ID: 66226, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trappc2provided by MGI
    Official Full Name
    trafficking protein particle complex 2provided by MGI
    Primary source
    MGI:MGI:1913476
    See related
    Ensembl:ENSMUSG00000079317 AllianceGenome:MGI:1913476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sedl; TRS20; MIP-2A; 1110066L09Rik; 1810064C02Rik
    Summary
    Predicted to enable transcription corepressor binding activity and transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of gene expression; and skeletal system development. Part of TRAPP complex. Is expressed in several structures, including eye; genitourinary system; gut; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 12.9), cortex adult (RPKM 11.5) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trappc2 in Genome Data Viewer
    Location:
    X F5; X 77.43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (165223747..165236136)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (166440702..166453140)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 8 Neighboring gene STARR-seq mESC enhancer starr_48252 Neighboring gene glycoprotein m6b Neighboring gene OFD1, centriole and centriolar satellite protein Neighboring gene STARR-positive B cell enhancer ABC_E11806 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:162917789-162917898 Neighboring gene RAB9, member RAS oncogene family Neighboring gene family with sequence similarity 154, member A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118266

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in COPII vesicle coating NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle coating NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TRAPP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TRAPPII protein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    trafficking protein particle complex subunit 2
    Names
    sedlin
    spondyloepiphyseal dysplasia tarda protein
    spondyloepiphyseal dysplasia, late

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313722.1NP_001300651.1  trafficking protein particle complex subunit 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction and lacks an alternate 3' coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK002658, AK007951, BC099551
      Consensus CDS
      CCDS85828.1
      UniProtKB/TrEMBL
      A2AFP1
      Related
      ENSMUSP00000107811.2, ENSMUST00000112192.8
      Conserved Domains (1) summary
      cl21566
      Location:969
      Sedlin_N; Sedlin, N-terminal conserved region
    2. NM_025432.4NP_079708.2  trafficking protein particle complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_079708.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002658, BC099551
      Consensus CDS
      CCDS41208.1
      UniProtKB/Swiss-Prot
      Q8BP61, Q9CQF5, Q9CQP2, Q9D0V3, Q9DCM3
      UniProtKB/TrEMBL
      Q5J9A9
      Related
      ENSMUSP00000112195.2, ENSMUST00000116495.8
      Conserved Domains (1) summary
      cd14825
      Location:4138
      TRAPPC2_sedlin; Trafficking protein particle complex subunit 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      165223747..165236136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003953020.2 RNA Sequence