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    Spi1 Spi-1 proto-oncogene [ Mus musculus (house mouse) ]

    Gene ID: 20375, updated on 4-Jan-2025

    Summary

    Official Symbol
    Spi1provided by MGI
    Official Full Name
    Spi-1 proto-oncogeneprovided by MGI
    Primary source
    MGI:MGI:98282
    See related
    Ensembl:ENSMUSG00000002111 AllianceGenome:MGI:98282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dis1; PU.1; Dis-1; Sfpi1; Spi-1; Sfpi-1; Tcfpu1; Tfpu.1
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and histone deacetylase binding activity. Involved in several processes, including lymphocyte differentiation; regulation of macromolecule biosynthetic process; and regulation of myeloid leukocyte mediated immunity. Acts upstream of or within several processes, including apoptotic process involved in blood vessel morphogenesis; hemopoiesis; and regulation of DNA-templated transcription. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute myeloid leukemia. Human ortholog(s) of this gene implicated in agammaglobulinemia 10. Orthologous to human SPI1 (Spi-1 proto-oncogene). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in spleen adult (RPKM 51.8), lung adult (RPKM 18.0) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Spi1 in Genome Data Viewer
    Location:
    2 E1; 2 50.44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90912750..90946104)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91082374..91115759)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 13 Neighboring gene STARR-positive B cell enhancer ABC_E2041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90910894-90911077 Neighboring gene predicted gene, 57833 Neighboring gene predicted gene, 39874 Neighboring gene STARR-positive B cell enhancer ABC_E4476 Neighboring gene STARR-positive B cell enhancer ABC_E4477 Neighboring gene STARR-seq mESC enhancer starr_05105 Neighboring gene STARR-seq mESC enhancer starr_05107 Neighboring gene myosin binding protein C, cardiac Neighboring gene MAP-kinase activating death domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (23)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription repressor activity  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
    enables NFAT protein binding PubMed 
    enables RNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables STAT family protein binding  
    enables chromatin binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding  
    enables histone deacetylase binding PubMed 
    enables molecular adaptor activity  
    enables protein binding PubMed 
    enables protein sequestering activity PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 63
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect TRAIL-activated apoptotic signaling pathway  
    acts_upstream_of_or_within anatomical structure regression PubMed 
    acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis PubMed 
    involved_in cell differentiation  
    involved_in defense response to tumor cell  
    involved_in endothelial to hematopoietic transition PubMed 
    acts_upstream_of_or_within erythrocyte differentiation PubMed 
    involved_in follicular B cell differentiation PubMed 
    involved_in germinal center B cell differentiation PubMed 
    acts_upstream_of_or_within granulocyte differentiation PubMed 
    involved_in immature B cell differentiation PubMed 
    involved_in interleukin-6-mediated signaling pathway  
    involved_in lipopolysaccharide-mediated signaling pathway PubMed 
    acts_upstream_of_or_within lymphocyte differentiation PubMed 
    acts_upstream_of_or_within lymphoid progenitor cell differentiation PubMed 
    acts_upstream_of_or_within macrophage differentiation PubMed 
    acts_upstream_of_or_within myeloid dendritic cell differentiation PubMed 
    acts_upstream_of_or_within myeloid leukocyte differentiation PubMed 
    involved_in myeloid leukocyte differentiation  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of MHC class II biosynthetic process PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of adipose tissue development PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of neutrophil degranulation PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of protein localization to chromatin PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in oncogene-induced cell senescence PubMed 
    involved_in pericyte cell differentiation PubMed 
    involved_in positive regulation of B cell differentiation  
    involved_in positive regulation of B cell differentiation  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of antifungal innate immune response PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of miRNA transcription PubMed 
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of microglial cell mediated cytotoxicity PubMed 
    involved_in positive regulation of myeloid dendritic cell chemotaxis PubMed 
    involved_in positive regulation of p38MAPK cascade PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in pro-T cell differentiation PubMed 
    involved_in regulation of DNA-binding transcription factor activity PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of erythrocyte differentiation  
    involved_in regulation of myeloid progenitor cell differentiation PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within somatic stem cell population maintenance PubMed 
    involved_in transcription initiation-coupled chromatin remodeling PubMed 
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of_or_within vasculature development PubMed 
    Items 1 - 25 of 63
    Component Evidence Code Pubs
    located_in chromatin PubMed 
    located_in chromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription regulator complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcription factor PU.1
    Names
    31 kDa-transforming protein
    SFFV proviral integration 1 protein
    hematopoietic transcription factor PU.1
    spleen focus forming virus (SFFV) proviral integration oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378898.1NP_001365827.1  transcription factor PU.1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL691450
      UniProtKB/TrEMBL
      A0AAA9WUS1
      Conserved Domains (1) summary
      pfam00178
      Location:183264
      Ets; Ets-domain
    2. NM_001378899.1NP_001365828.1  transcription factor PU.1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691450
      Conserved Domains (1) summary
      pfam00178
      Location:142223
      Ets; Ets-domain
    3. NM_011355.2NP_035485.1  transcription factor PU.1 isoform 2

      See identical proteins and their annotated locations for NP_035485.1

      Status: VALIDATED

      Source sequence(s)
      AA239990, AA789819, AK153524, CJ187167
      Consensus CDS
      CCDS16425.1
      UniProtKB/Swiss-Prot
      P17433, Q99L57
      UniProtKB/TrEMBL
      A0AAA9WUS1, Q3U5L4
      Related
      ENSMUSP00000002180.8, ENSMUST00000002180.8
      Conserved Domains (1) summary
      smart00413
      Location:171259
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90912750..90946104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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