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    Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A [ Mus musculus (house mouse) ]

    Gene ID: 20361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sema7aprovided by MGI
    Official Full Name
    sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7Aprovided by MGI
    Primary source
    MGI:MGI:1306826
    See related
    Ensembl:ENSMUSG00000038264 AllianceGenome:MGI:1306826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Semal; CDw108; sema L; sema K1; H-Sema-L; M-Sema-L; H-Sema K1; 2900057C09Rik
    Summary
    Enables integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development; positive regulation of axon extension; and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is active in GABA-ergic synapse and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SEMA7A (semaphorin 7A (JohnMiltonHagen blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 69.7), cerebellum adult (RPKM 47.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sema7a in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57846879..57870148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57939596..57962865)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24249 Neighboring gene meiotic nuclear divisions 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_24251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57758633-57758820 Neighboring gene ubiquitin-like 7 (bone marrow stromal cell-derived) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57804760-57804959 Neighboring gene STARR-positive B cell enhancer ABC_E8291 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57816329-57816438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57819923-57820197 Neighboring gene STARR-seq mESC enhancer starr_24252 Neighboring gene STARR-positive B cell enhancer ABC_E2890 Neighboring gene STARR-seq mESC enhancer starr_24253 Neighboring gene Cyp11a1 promoter region Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Semaphorin 7A as a Potential Therapeutic Target for Multiple Sclerosis. Gutiérrez-Franco A, et al. Mol Neurobiol, 2017 Aug. PMID 27714632
    2. Semaphorin 7A plays a critical role in IgE-mediated airway inflammation in mice. Mizutani N, et al. Eur J Pharmacol, 2015 Oct 5. PMID 26144372
    3. Semaphorin 7a links nerve regeneration and inflammation in the cornea. Namavari A, et al. Invest Ophthalmol Vis Sci, 2012 Jul 9. PMID 22700709, Free PMC Article
    4. Semaphorin 7A promotes angiogenesis in an experimental corneal neovascularization model. Ghanem RC, et al. Curr Eye Res, 2011 Nov. PMID 21999225, Free PMC Article
    5. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Gan Y, et al. Arthritis Rheum, 2011 Aug. PMID 21484765, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells.
      Title: Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells.
    2. Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.
      Title: Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.
    3. Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin beta1 and mediates inflammation.
      Title: Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation.
    4. Knockdown of SEMA7A alleviates MPP[+] -induced apoptosis and inflammation in BV2 microglia via PPAR-gamma activation and MAPK inactivation.
      Title: Knockdown of SEMA7A alleviates MPP(+) -induced apoptosis and inflammation in BV2 microglia via PPAR-γ activation and MAPK inactivation.
    5. SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.
      Title: SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.
    6. Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions.
      Title: Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions.
    7. Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.
      Title: Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.
    8. A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.
      Title: A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.
    9. The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
      Title: The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
    10. Sema7A is crucial for resolution of severe inflammation.
      Title: Sema7A is crucial for resolution of severe inflammation.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables neuropilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory lobe development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within olfactory lobe development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of axon extension IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macrophage cytokine production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    semaphorin-7A
    Names
    semaphorin-K1
    semaphorin-L

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011352.3 → NP_035482.1  semaphorin-7A precursor

      See identical proteins and their annotated locations for NP_035482.1

      Status: VALIDATED

      Source sequence(s)
      AC165246
      Consensus CDS
      CCDS23235.1
      UniProtKB/Swiss-Prot
      O88371, Q9QUR8
      Related
      ENSMUSP00000042211.8, ENSMUST00000043059.9
      Conserved Domains (3) summary
      cd11243
      Location:70 → 489
      Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)
      pfam01437
      Location:491 → 518
      PSI; Plexin repeat
      cl11960
      Location:547 → 617
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57846879..57870148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244149.1 → XP_030100009.1  semaphorin-7A isoform X2

      Conserved Domains (4) summary
      pfam01437
      Location:275 → 324
      PSI; Plexin repeat
      cd00096
      Location:331 → 337
      Ig; Ig strand A [structural motif]
      cl11960
      Location:331 → 401
      Ig; Immunoglobulin domain
      cl15693
      Location:1 → 273
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    2. XM_006510889.4 → XP_006510952.1  semaphorin-7A isoform X1

      See identical proteins and their annotated locations for XP_006510952.1

      Conserved Domains (3) summary
      smart00423
      Location:333 → 360
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:389 → 459
      Ig; Immunoglobulin domain
      cl15693
      Location:2 → 331
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    3. XM_036154744.1 → XP_036010637.1  semaphorin-7A isoform X2

      Conserved Domains (4) summary
      pfam01437
      Location:275 → 324
      PSI; Plexin repeat
      cd00096
      Location:331 → 337
      Ig; Ig strand A [structural motif]
      cl11960
      Location:331 → 401
      Ig; Immunoglobulin domain
      cl15693
      Location:1 → 273
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    4. XM_006510888.4 → XP_006510951.1  semaphorin-7A isoform X1

      See identical proteins and their annotated locations for XP_006510951.1

      Conserved Domains (3) summary
      smart00423
      Location:333 → 360
      PSI; domain found in Plexins, Semaphorins and Integrins
      cl11960
      Location:389 → 459
      Ig; Immunoglobulin domain
      cl15693
      Location:2 → 331
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUR8.1 GenPept UniProtKB/Swiss-Prot:Q9QUR8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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