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    Vwde von Willebrand factor D and EGF domains [ Mus musculus (house mouse) ]

    Gene ID: 232585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vwdeprovided by MGI
    Official Full Name
    von Willebrand factor D and EGF domainsprovided by MGI
    Primary source
    MGI:MGI:2685313
    See related
    Ensembl:ENSMUSG00000079679 AllianceGenome:MGI:2685313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm467
    Summary
    Predicted to be located in extracellular region. Is expressed in tooth. Orthologous to human VWDE (von Willebrand factor D and EGF domains). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Vwde in Genome Data Viewer
    Location:
    6 A1; 6 5.64 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13156439..13224964, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13156440..13224965, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106B Neighboring gene STARR-seq mESC enhancer starr_15191 Neighboring gene predicted gene, 24985 Neighboring gene STARR-positive B cell enhancer mm9_chr6:13230982-13231283 Neighboring gene predicted gene 725 Neighboring gene STARR-seq mESC enhancer starr_15192 Neighboring gene RIKEN cDNA 1700016P04 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation. Iwata K, et al. J Cell Physiol, 2022 Mar. PMID 34957547
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation.
      Title: von Willebrand factor D and EGF domains regulate ameloblast differentiation and enamel formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor D and EGF domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013757.2 → NP_001013779.2  von Willebrand factor D and EGF domain-containing protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001013779.2

      Status: PROVISIONAL

      Source sequence(s)
      AC158682, BC076621
      Consensus CDS
      CCDS51722.1
      UniProtKB/Swiss-Prot
      B9EKY3, Q6DFV8
      Related
      ENSMUSP00000058110.6, ENSMUST00000054530.7
      Conserved Domains (1) summary
      cl02516
      Location:436 → 588
      VWD; von Willebrand factor type D domain

    2. NM_001368871.1 → NP_001355800.1  von Willebrand factor D and EGF domain-containing protein isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158682
      Consensus CDS
      CCDS90028.1
      UniProtKB/TrEMBL
      A0A0N4SVZ4
      Related
      ENSMUSP00000145311.2, ENSMUST00000203074.3
      Conserved Domains (3) summary
      smart00179
      Location:1256 → 1294
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:1222 → 1254
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02516
      Location:436 → 588
      VWD; von Willebrand factor type D domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      13156439..13224964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DFV8.2 GenPept UniProtKB/Swiss-Prot:Q6DFV8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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