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    Shc4 SHC (Src homology 2 domain containing) family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 271849, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shc4provided by MGI
    Official Full Name
    SHC (Src homology 2 domain containing) family, member 4provided by MGI
    Primary source
    MGI:MGI:2655364
    See related
    Ensembl:ENSMUSG00000035109 AllianceGenome:MGI:2655364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RaLP; Gm685; 6230417E10Rik; 9930029B02Rik
    Summary
    Enables protein domain specific binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; sensory organ; and skin. Orthologous to human SHC4 (SHC adaptor protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 3.4), testis adult (RPKM 2.5) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Shc4 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125469359..125566085, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125627439..125724148, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05588 Neighboring gene fibrillin 1 Neighboring gene STARR-seq mESC enhancer starr_05589 Neighboring gene centrosomal protein 152 Neighboring gene STARR-positive B cell enhancer ABC_E1254 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9530 Neighboring gene STARR-seq mESC enhancer starr_05593 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125550365-125550474 Neighboring gene predicted gene, 35231 Neighboring gene STARR-positive B cell enhancer ABC_E11155 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene SECIS binding protein 2-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125602741-125602942 Neighboring gene STARR-positive B cell enhancer ABC_E5976 Neighboring gene STARR-positive B cell enhancer ABC_E7857 Neighboring gene STARR-positive B cell enhancer ABC_E11156 Neighboring gene COP9 signalosome subunit 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    SHC-transforming protein 4
    Names
    SH2 domain protein C4
    SHC-transforming protein D
    mShcD
    novel phosphotyrosine interaction domain (PTB/PID) and SH2 domains containing protein
    rai-like protein RaLP
    src homology 2 domain-containing-transforming protein C4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199022.3NP_950187.1  SHC-transforming protein 4

      See identical proteins and their annotated locations for NP_950187.1

      Status: VALIDATED

      Source sequence(s)
      AL844580, AL929166
      Consensus CDS
      CCDS16678.1
      UniProtKB/Swiss-Prot
      Q6S5L9
      Related
      ENSMUSP00000043146.8, ENSMUST00000042246.14
      Conserved Domains (2) summary
      cd09925
      Location:513614
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:181347
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125469359..125566085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162265.1XP_036018158.1  SHC-transforming protein 4 isoform X2

      UniProtKB/TrEMBL
      A2AUN0
      Related
      ENSMUSP00000106106.2, ENSMUST00000110480.8
      Conserved Domains (2) summary
      cd09925
      Location:227328
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cl17171
      Location:161
      PH-like; Pleckstrin homology-like domain
    2. XM_006499655.5XP_006499718.3  SHC-transforming protein 4 isoform X1

      Conserved Domains (2) summary
      cd09925
      Location:297398
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cl17171
      Location:63131
      PH-like; Pleckstrin homology-like domain