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    Gbgt1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 227671, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gbgt1provided by MGI
    Official Full Name
    globoside alpha-1,3-N-acetylgalactosaminyltransferase 1provided by MGI
    Primary source
    MGI:MGI:2449143
    See related
    Ensembl:ENSMUSG00000026829 AllianceGenome:MGI:2449143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fs; Fgs
    Summary
    Enables globoside alpha-N-acetylgalactosaminyltransferase activity. Predicted to be involved in globoside metabolic process and lipid glycosylation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and vesicle. Is expressed in intestine; male reproductive gland or organ; nervous system; and stomach. Orthologous to human GBGT1 (globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 2.4), large intestine adult (RPKM 2.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gbgt1 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28369368..28396048)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28479354..28506030)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04020 Neighboring gene piercer of microtubule wall 1 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_04022 Neighboring gene STARR-positive B cell enhancer ABC_E10087 Neighboring gene ral guanine nucleotide dissociation stimulator Neighboring gene VISTA enhancer mm337 Neighboring gene carboxyl ester lipase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Forssman synthetase expression results in diminished shiga toxin susceptibility: a role for glycolipids in determining host-microbe interactions. Elliott SP, et al. Infect Immun, 2003 Nov. PMID 14573676, Free PMC Article
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123927

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables globoside alpha-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables globoside alpha-N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in globoside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid glycosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
    Names
    forssman glycolipid synthase
    forssman glycolipid synthetase
    NP_001411715.1
    NP_631936.2
    XP_006497981.1
    XP_006497985.1
    XP_017172754.1
    XP_017172756.1
    XP_017172757.1
    XP_017172758.1
    XP_036016677.1
    XP_036016680.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424786.1 → NP_001411715.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772249

    2. NM_139197.3 → NP_631936.2  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_631936.2

      Status: VALIDATED

      Source sequence(s)
      AL772249
      Consensus CDS
      CCDS15839.1
      UniProtKB/Swiss-Prot
      Q3KPA1, Q8CJF3, Q8VI38
      Related
      ENSMUSP00000127071.2, ENSMUST00000163121.8
      Conserved Domains (1) summary
      pfam03414
      Location:60 → 346
      Glyco_transf_6; Glycosyltransferase family 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28369368..28396048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317269.3 → XP_017172758.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X3

      Conserved Domains (1) summary
      cl11394
      Location:34 → 316
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    2. XM_017317265.3 → XP_017172754.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam03414
      Location:75 → 361
      Glyco_transf_6; Glycosyltransferase family 6

    3. XM_006497918.4 → XP_006497981.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_006497981.1

      UniProtKB/Swiss-Prot
      Q3KPA1, Q8CJF3, Q8VI38
      Conserved Domains (1) summary
      pfam03414
      Location:60 → 346
      Glyco_transf_6; Glycosyltransferase family 6

    4. XM_036160784.1 → XP_036016677.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam03414
      Location:75 → 361
      Glyco_transf_6; Glycosyltransferase family 6

    5. XM_017317267.3 → XP_017172756.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam03414
      Location:75 → 361
      Glyco_transf_6; Glycosyltransferase family 6

    6. XM_036160787.1 → XP_036016680.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3KPA1, Q8CJF3, Q8VI38
      Conserved Domains (1) summary
      pfam03414
      Location:60 → 346
      Glyco_transf_6; Glycosyltransferase family 6

    7. XM_017317268.2 → XP_017172757.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam03414
      Location:75 → 361
      Glyco_transf_6; Glycosyltransferase family 6

    8. XM_006497922.2 → XP_006497985.1  globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 isoform X4

      Conserved Domains (1) summary
      pfam03414
      Location:13 → 299
      Glyco_transf_6; Glycosyltransferase family 6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI38.2 GenPept UniProtKB/Swiss-Prot:Q8VI38

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