Cplx4 complexin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cplx4provided by MGI
Official Full Name: complexin 4provided by MGI
Primary source: MGI:MGI:2685803
See related: Ensembl:ENSMUSG00000024519 AllianceGenome:MGI:2685803
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CPXIV; Gm957; A930004D23Rik
Summary: Enables SNARE binding activity. Acts upstream of or within regulation of neurotransmitter secretion. Located in synapse. Is expressed in retina outer nuclear layer. Orthologous to human CPLX4 (complexin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 39.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (66088793..66103249, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (65955722..65970178, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The findings of this study reveal a suppressing action of Cplx3/4 on tonic neurotransmitter release, a facilitating action on evoked release, and a regulatory role of Cplx3/4 in the adaptation-dependent availability of synaptic vesicles at mouse photoreceptor ribbon synapses.
Title: Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.
The lack of Cplx 3 and Cplx 4 differentially impacts the ON and OFF pathways in the retina is corroborated by localization studies of Cplx 3 and Cplx 4 in the retina.
Title: The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina.
Results show that complexin 3 and complexin 4 are essential regulators of transmitter release at retinal ribbon synapses.
Title: Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.
Disruption in complexin I is associated with profound ataxia with a complex phenotype that includes exploratory and habituation deficits
Title: Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: complexin-4

Names: CPX IV; complexin IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.