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    Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 [ Mus musculus (house mouse) ]

    Gene ID: 20540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc7a7provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 7provided by MGI
    Primary source
    MGI:MGI:1337120
    See related
    Ensembl:ENSMUSG00000000958 AllianceGenome:MGI:1337120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    my+lat1
    Summary
    Enables basic amino acid transmembrane transporter activity. Acts upstream of or within regulation of arginine metabolic process. Predicted to be located in basolateral plasma membrane. Is expressed in heart; intestine; metanephros; and testis. Used to study lysinuric protein intolerance. Human ortholog(s) of this gene implicated in lysinuric protein intolerance. Orthologous to human SLC7A7 (solute carrier family 7 member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 116.6), large intestine adult (RPKM 74.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc7a7 in Genome Data Viewer
    Location:
    14 C2; 14 27.76 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54606899..54657525, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54369442..54420068, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43305 Neighboring gene eukaryotic translation initiation factor 4H pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3114 Neighboring gene oxidase assembly 1-like Neighboring gene STARR-seq mESC enhancer starr_36728 Neighboring gene STARR-positive B cell enhancer ABC_E3115 Neighboring gene STARR-seq mESC enhancer starr_36729 Neighboring gene STARR-seq mESC enhancer starr_36730 Neighboring gene STARR-seq mESC enhancer starr_36733 Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene matrix metallopeptidase 14 (membrane-inserted)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis. Hagen CM, et al. World J Gastroenterol, 2022 Mar 14. PMID 35431492, Free PMC Article
    2. Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7. Zuo T, et al. J Proteome Res, 2020 Apr 3. PMID 32155069
    3. A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance. Stroup BM, et al. Hum Mol Genet, 2020 Aug 3. PMID 32504080, Free PMC Article
    4. Regulation of renal amino acid transporters during metabolic acidosis. Moret C, et al. Am J Physiol Renal Physiol, 2007 Feb. PMID 17003226
    5. Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells. Omidi Y, et al. Cell Biochem Funct, 2008 Apr. PMID 18210381

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.
      Title: Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis.
    2. A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance.
      Title: A global Slc7a7 knockout mouse model demonstrates characteristic phenotypes of human lysinuric protein intolerance.
    3. Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7.
      Title: Quantitative Proteomics Reveals the Development of HBV-Associated Glomerulonephritis Triggered by the Downregulation of SLC7A7.
    4. The expression of Mct8 and L-type amino acid transporters Lat2 and Lat1 are determined in brain neurons during development.
      Title: Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells.
    5. LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP mRNAs were not.
      Title: The monocarboxylate transporter 8 and L-type amino acid transporters 1 and 2 are expressed in mouse skeletons and in osteoblastic MC3T3-E1 cells.
    6. System L functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids.
      Title: Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells.
    7. The Slc7a7(-/-) mouse displayed intrauterine growth restriction, leading to neonatal lethality. After heavy protein ingestion, the surviving adult animals presented metabolic derangement consistent with lysinuric protein intolerance.
      Title: Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance.
    8. selective regulation of SNAT3 and y(+)LAT1 expression may serve a major role in the renal adaptation to acid secretion and thus for systemic acid-base balance.
      Title: Regulation of renal amino acid transporters during metabolic acidosis.
    9. Increased LAT1 expression can be induced by lipid oxidation products relevant to inflammatory responses in atherogenesis. LAT1 mediates lysophosphatidylcholine-enhanced cytokine production by endothelial cells.
      Title: Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables basic amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-leucine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of arginine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of arginine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Y+L amino acid transporter 1
    Names
    solute carrier family 7 member 7
    y(+)L-type amino acid transporter 1
    y+LAT-1
    y+LAT1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253679.1 → NP_001240608.1  Y+L amino acid transporter 1

      See identical proteins and their annotated locations for NP_001240608.1

      Status: VALIDATED

      Source sequence(s)
      AC206013
      Consensus CDS
      CCDS27087.1
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Related
      ENSMUSP00000154533.2, ENSMUST00000226753.2
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    2. NM_001253680.1 → NP_001240609.1  Y+L amino acid transporter 1

      See identical proteins and their annotated locations for NP_001240609.1

      Status: VALIDATED

      Source sequence(s)
      AK152637, AV487330, CB953352
      Consensus CDS
      CCDS27087.1
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Related
      ENSMUSP00000000984.5, ENSMUST00000000984.9
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    3. NM_001379497.1 → NP_001366426.1  Y+L amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC206013
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    4. NM_001379498.1 → NP_001366427.1  Y+L amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC206013
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    5. NM_001379499.1 → NP_001366428.1  Y+L amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC206013
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Related
      ENSMUSP00000143091.2, ENSMUST00000195970.5
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    6. NM_001424591.1 → NP_001411520.1  Y+L amino acid transporter 1

      Status: VALIDATED

      Source sequence(s)
      AC206013
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8

    7. NM_011405.4 → NP_035535.2  Y+L amino acid transporter 1

      See identical proteins and their annotated locations for NP_035535.2

      Status: VALIDATED

      Source sequence(s)
      AK151718, AV487330, BY032471
      Consensus CDS
      CCDS27087.1
      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Related
      ENSMUSP00000143743.2, ENSMUST00000197440.5
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54606899..54657525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247702.1 → XP_030103562.1  Y+L amino acid transporter 1 isoform X1

      Conserved Domains (1) summary
      TIGR00911
      Location:107 → 580
      2A0308; L-type amino acid transporter

    2. XM_036158528.1 → XP_036014421.1  Y+L amino acid transporter 1 isoform X4

      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    3. XM_006518746.2 → XP_006518809.1  Y+L amino acid transporter 1 isoform X2

      Conserved Domains (1) summary
      TIGR00911
      Location:44 → 517
      2A0308; L-type amino acid transporter

    4. XM_006518751.3 → XP_006518814.1  Y+L amino acid transporter 1 isoform X4

      See identical proteins and their annotated locations for XP_006518814.1

      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    5. XM_006518753.1 → XP_006518816.1  Y+L amino acid transporter 1 isoform X4

      See identical proteins and their annotated locations for XP_006518816.1

      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    6. XM_006518755.5 → XP_006518818.1  Y+L amino acid transporter 1 isoform X4

      See identical proteins and their annotated locations for XP_006518818.1

      UniProtKB/Swiss-Prot
      Q9QWS1, Q9Z1K8
      Conserved Domains (1) summary
      TIGR00911
      Location:21 → 494
      2A0308; L-type amino acid transporter

    7. XM_030247703.1 → XP_030103563.1  Y+L amino acid transporter 1 isoform X3

      Conserved Domains (1) summary
      TIGR00911
      Location:42 → 515
      2A0308; L-type amino acid transporter

    8. XM_030247705.1 → XP_030103565.1  Y+L amino acid transporter 1 isoform X5

      Conserved Domains (1) summary
      TIGR00911
      Location:3 → 328
      2A0308; L-type amino acid transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1K8.1 GenPept UniProtKB/Swiss-Prot:Q9Z1K8

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