Wnt16 wingless-type MMTV integration site family, member 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt16provided by MGI
Official Full Name: wingless-type MMTV integration site family, member 16provided by MGI
Primary source: MGI:MGI:2136018
See related: Ensembl:ENSMUSG00000029671 AllianceGenome:MGI:2136018
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E130309I19Rik
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within bone remodeling and cardiac epithelial to mesenchymal transition. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and heart. Orthologous to human WNT16 (Wnt family member 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in ovary adult (RPKM 2.9), subcutaneous fat pad adult (RPKM 1.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 9.22 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (22288179..22298521)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (22288178..22298522)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
Title: Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
Title: WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development.
Title: Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development.
WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling.
Title: WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling.
WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1beta induced inflammatory response by regulation of RUNX2/MMP13 cascade.
Title: WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade.
Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice.
Title: Wnt16 Overexpression in Osteoblasts Increases the Subchondral Bone Mass but has no Impact on Osteoarthritis in Young Adult Female Mice.
Lower WNT16 expression in patients with adolescent idiopathic scoliosis - potential link to lower bone mass in AIS?
Title: Lower WNT16 expression in patients with adolescent idiopathic scoliosis - potential link to lower bone mass in AIS?
GC treatment with dexamethasone (DEX) decreased Wnt16 mRNA levels in murine bone marrow stromal cells (mBMSCs) time- and dose-dependently.
Title: Glucocorticoids suppress Wnt16 expression in osteoblasts in vitro and in vivo.
WNT16 is a crucial regulator of cortical bone thickness in young adult and old mice. New treatment strategies targeting the adult regulation of WNT16 might be useful to reduce fracture risk at cortical bone sites.
Title: Inducible Wnt16 inactivation: WNT16 regulates cortical bone thickness in adult mice.
Glucocorticoids (GC) treatment decreases Wnt16 mRNA levels in bone and WNT16 overexpression partly protects against GC-induced bone loss.
Title: WNT16 overexpression partly protects against glucocorticoid-induced bone loss.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488989

Wnt16 (e-PCR), detects polymorphism
- UniSTS:527134

Wnt16 (e-PCR), detects polymorphism
- UniSTS:471855

Wnt16 (e-PCR), detects polymorphism
- UniSTS:508508

Wnt16 (e-PCR), detects polymorphism
- UniSTS:508509

Wnt16 (e-PCR), detects polymorphism
- UniSTS:507314

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative stress-induced premature senescence	IEA Inferred from Electronic Annotation more info
involved_in oxidative stress-induced premature senescence	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	IEA Inferred from Electronic Annotation more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Wnt-16

Names: wingless-related MMTV integration site 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053116.4 → NP_444346.3 protein Wnt-16 precursor

See identical proteins and their annotated locations for NP_444346.3

Status: VALIDATED

Source sequence(s)

AK053805, AK054110, BC115925

Consensus CDS

CCDS19936.1

UniProtKB/Swiss-Prot

Q14BF7, Q9QYS1

UniProtKB/TrEMBL

Q8C6P4

Related

ENSMUSP00000031681.4, ENSMUST00000031681.10

Conserved Domains (1) summary

pfam00110
Location:52 → 364

wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

22288179..22298521

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505214.5 → XP_006505277.1 protein Wnt-16 isoform X1

See identical proteins and their annotated locations for XP_006505277.1

UniProtKB/TrEMBL

H3BJ29, Q8BRT3

Related

ENSMUSP00000135016.2, ENSMUST00000148639.2

Conserved Domains (1) summary

cl38924
Location:52 → 210

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family