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    Cd244a CD244 molecule A [ Mus musculus (house mouse) ]

    Gene ID: 18106, updated on 3-Dec-2024

    Summary

    Official Symbol
    Cd244aprovided by MGI
    Official Full Name
    CD244 molecule Aprovided by MGI
    Primary source
    MGI:MGI:109294
    See related
    Ensembl:ENSMUSG00000004709 AllianceGenome:MGI:109294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2B4; C9.1; Ly90; NAIL; Nmrk; Cd244; NKR2B4; SLAMF4; F730046O15Rik
    Summary
    Predicted to enable MHC class I protein binding activity. Involved in myeloid dendritic cell activation; natural killer cell activation involved in immune response; and positive regulation of lymphocyte proliferation. Located in external side of plasma membrane. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 1.6), large intestine adult (RPKM 0.7) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cd244a in Genome Data Viewer
    Location:
    1 H3; 1 79.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171386761..171412884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171558718..171585316)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene intelectin 1 (galactofuranose binding) Neighboring gene predicted gene, 37450 Neighboring gene STARR-positive B cell enhancer ABC_E9497 Neighboring gene STARR-seq mESC enhancer starr_03041 Neighboring gene predicted gene, 35200 Neighboring gene lymphocyte antigen 9 Neighboring gene STARR-positive B cell enhancer ABC_E5848 Neighboring gene SLAM family member 7 Neighboring gene microRNA 7683

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    natural killer cell receptor 2B4
    Names
    CD244 natural killer cell receptor 2B4
    NK cell receptor 2B4
    NK cell type I receptor protein 2B4
    SLAM family member 4
    non-MHC restricted killing associated
    signaling lymphocytic activation molecule 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001423738.1NP_001410667.1  natural killer cell receptor 2B4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC083892
      UniProtKB/TrEMBL
      Q3S4B1
    2. NM_018729.2NP_061199.2  natural killer cell receptor 2B4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061199.2

      Status: VALIDATED

      Source sequence(s)
      AC083892, AF082803, AK137505, BY207581
      Consensus CDS
      CCDS35778.1
      UniProtKB/Swiss-Prot
      O88654, Q07763, Q3UV86, Q9JIE0
      UniProtKB/TrEMBL
      Q3S4B1
      Related
      ENSMUSP00000004829.8, ENSMUST00000004829.13
      Conserved Domains (1) summary
      pfam11465
      Location:22129
      Receptor_2B4; Natural killer cell receptor 2B4

    RNA

    1. NR_187115.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083892
    2. NR_187116.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC083892

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171386761..171412884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)