U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ppp1r8 protein phosphatase 1, regulatory subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 100336, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ppp1r8provided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 8provided by MGI
    Primary source
    MGI:MGI:2140494
    See related
    Ensembl:ENSMUSG00000028882 AllianceGenome:MGI:2140494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIPP1; 6330548N22Rik
    Summary
    Enables protein phosphatase regulator activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nuclear speck. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; adrenal gland; and brain. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.1), CNS E14 (RPKM 26.4) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ppp1r8 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132554235..132570480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132826924..132843169, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E426 Neighboring gene STARR-positive B cell enhancer ABC_E6229 Neighboring gene replication protein A2 Neighboring gene thymocyte selection associated family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2125 Neighboring gene STARR-positive B cell enhancer ABC_E4675 Neighboring gene STARR-positive B cell enhancer ABC_E3521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132399078-132399187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132399191-132399374 Neighboring gene predicted gene, 22767 Neighboring gene syntaxin 12 Neighboring gene prostaglandin-endoperoxide synthase 2 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice. Jonkhout MCM, et al. J Invest Dermatol, 2024 Oct. PMID 38431220
    2. Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation. Verbinnen I, et al. J Invest Dermatol, 2020 Aug. PMID 31972250, Free PMC Article
    3. Nuclear protein phosphatase-1: an epigenetic regulator of fear memory and amygdala long-term potentiation. Koshibu K, et al. Neuroscience, 2011 Jan 26. PMID 21093547
    4. Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development. McKee C, et al. Mol Neurobiol, 2022 Dec. PMID 36198882, Free PMC Article
    5. Interactor-mediated nuclear translocation and retention of protein phosphatase-1. Lesage B, et al. J Biol Chem, 2004 Dec 31. PMID 15501817

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice.
      Title: Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice.
    2. Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development.
      Title: Nuclear Inhibitor of Protein Phosphatase 1 (NIPP1) Regulates CNS Tau Phosphorylation and Myelination During Development.
    3. Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation.
      Title: Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation.
    4. We conclude that NIPP1 is essential for mammalian spermatogenesis because it is indispensable for the proliferation and survival of progenitor germ cells, including (un)differentiated spermatogonia.
      Title: The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis.
    5. NIPP1 deletion abrogated PP1-mediated EZH2 dephosphorylation at two cyclin-dependent kinase sites (Thr-345/487), thereby generating hyperphosphorylated EZH2, which is a substrate for proteolytic degradation.
      Title: The deletion of the protein phosphatase 1 regulator NIPP1 in testis causes hyperphosphorylation and degradation of the histone methyltransferase EZH2.
    6. NIPP1 does not regulate the proliferation of hepatocytes but is a suppressor of biliary epithelial cell proliferation, including progenitor cells, in the adult liver.
      Title: Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver.
    7. activation of the RAGE by advanced glycation end products or other ligands suppresses NIPP1 expression in diabetic nephropathy, contributes to podocyte hypertrophy, and glomerular inflammation
      Title: Activation of the receptor for advanced glycation end products induces nuclear inhibitor of protein phosphatase-1 suppression.
    8. Required for the global trimethylation of Histone 3 at Lysine 27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2.
      Title: The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing.
    9. NIPP1(-/-) embryos showed severely retarded growth at embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early embryonic lethality was not associated with increased apoptosis but correlated with impaired cell proliferation.
      Title: The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.
    10. NIPP1 has a role in the nuclear targeting and/or retention of PP1
      Title: Interactor-mediated nuclear translocation and retention of protein phosphatase-1.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC38560

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nuclear inhibitor of protein phosphatase 1
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 8

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290725.1 → NP_001277654.1  nuclear inhibitor of protein phosphatase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AK032022, BQ749177, BY257668, BY293277, CK625884
      Consensus CDS
      CCDS71482.1
      UniProtKB/TrEMBL
      A2ADR8
      Related
      ENSMUSP00000101539.2, ENSMUST00000105919.2
      Conserved Domains (2) summary
      cd00060
      Location:27 → 119
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam11945
      Location:98 → 212
      WASH_WAHD; WAHD domain of WASH complex

    2. NM_001355198.1 → NP_001342127.1  nuclear inhibitor of protein phosphatase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK032022, AL671190, BB855371, BQ749177, BY293277
      Conserved Domains (2) summary
      cd00060
      Location:53 → 145
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam11945
      Location:124 → 238
      WASH_WAHD; WAHD domain of WASH complex

    3. NM_001355199.1 → NP_001342128.1  nuclear inhibitor of protein phosphatase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK032022, AL671190, BB855371, BQ749177, BY293277
      Conserved Domains (2) summary
      cd00060
      Location:53 → 145
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam11945
      Location:124 → 238
      WASH_WAHD; WAHD domain of WASH complex

    4. NM_146154.3 → NP_666266.1  nuclear inhibitor of protein phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_666266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK032022, BQ749177, BY293277
      Consensus CDS
      CCDS18736.1
      UniProtKB/Swiss-Prot
      Q8C087, Q8R3G1
      Related
      ENSMUSP00000030702.8, ENSMUST00000030702.14
      Conserved Domains (2) summary
      cd00060
      Location:27 → 119
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam11945
      Location:98 → 212
      WASH_WAHD; WAHD domain of WASH complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132554235..132570480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3G1.1 GenPept UniProtKB/Swiss-Prot:Q8R3G1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools