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    Sytl1 synaptotagmin-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 269589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sytl1provided by MGI
    Official Full Name
    synaptotagmin-like 1provided by MGI
    Primary source
    MGI:MGI:1933365
    See related
    Ensembl:ENSMUSG00000028860 AllianceGenome:MGI:1933365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slp1; PSGL-1; 9030417L18
    Summary
    Enables neurexin family protein binding activity. Involved in exocytosis. Located in melanosome and plasma membrane. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human SYTL1 (synaptotagmin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 54.8), colon adult (RPKM 46.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sytl1 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132980401..132990398, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133253090..133263087, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CD164 sialomucin-like 2 Neighboring gene ficolin C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11620 Neighboring gene STARR-seq mESC enhancer starr_11622 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer mm9_chr4:132865900-132866201 Neighboring gene STARR-positive B cell enhancer ABC_E7995 Neighboring gene STARR-seq mESC enhancer starr_11626 Neighboring gene STARR-seq mESC enhancer starr_11627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. Ramadass M, et al. J Leukoc Biol, 2019 Jun. PMID 30748033, Free PMC Article
    2. The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane. Wang H, et al. Mol Biol Cell, 2013 Feb. PMID 23223571, Free PMC Article
    3. Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Saegusa C, et al. Arch Biochem Biophys, 2008 Jul 1. PMID 18477466
    4. Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Johnson JL, et al. Mol Biol Cell, 2012 May. PMID 22438581, Free PMC Article
    5. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. Kurz AR, et al. J Clin Invest, 2016 Nov 1. PMID 27701149, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results suggest that defective Rac1-GTP recycling from the uropod affects directionality and highlight JFC1-mediated Rac1 trafficking as a potential target to regulate chemotaxis in inflammation and immunity.
      Title: The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration.
    2. Granuphilin and exophilin7, differentially regulate the exocytosis of either stably or minimally docked granules, respectively.
      Title: The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
    3. These results suggest that both Slp1 and Slp2-a may form part of a docking complex, capturing secretory lysosomes at the immunological synapse.
      Title: Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
    4. Expression of Rab27B-binding proteinm Sytl1 in pancreatic acinar cells and its involvement in amylase secretion are reported.
      Title: Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion.
    5. Jfc1/synaptotagmin-like protein 1 (Slp1) contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slp1/Jfc1 specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082).
      Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables neurexin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurexin family protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    synaptotagmin-like protein 1
    Names
    exophilin-7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031393.2 → NP_113570.2  synaptotagmin-like protein 1

      See identical proteins and their annotated locations for NP_113570.2

      Status: VALIDATED

      Source sequence(s)
      AA856092, AI553427, AK131162
      Consensus CDS
      CCDS38902.1
      UniProtKB/Swiss-Prot
      Q99J26, Q99N80
      UniProtKB/TrEMBL
      A2AE94
      Related
      ENSMUSP00000030674.8, ENSMUST00000030674.8
      Conserved Domains (4) summary
      pfam06390
      Location:92 → 230
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd04020
      Location:405 → 561
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:273 → 392
      C2; C2 domain
      cl22851
      Location:35 → 99
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132980401..132990398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250265.1 → XP_011248567.1  synaptotagmin-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011248567.1

      UniProtKB/Swiss-Prot
      Q99J26, Q99N80
      UniProtKB/TrEMBL
      A2AE94
      Conserved Domains (4) summary
      pfam06390
      Location:92 → 230
      NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
      cd04020
      Location:405 → 561
      C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
      cl14603
      Location:273 → 392
      C2; C2 domain
      cl22851
      Location:35 → 99
      PHD_SF; PHD finger superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N80.2 GenPept UniProtKB/Swiss-Prot:Q99N80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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